White Sox vs. Guardians Prediction and Odds - Apr 19, 2022

The Cleveland Guardians square off with the Chicago White Sox in MLB action at Progressive Field on Tuesday, starting at 6:10PM EDT.

The Guardians will send Shane Bieber (0-0, 2.70 ERA) to the mound, pitting him against Dallas Keuchel (1-0, 5.40 ERA) for the White Sox.

Dimers' best betting picks for White Sox vs. Guardians, as well as game predictions and best odds, are detailed below.

Who will win White Sox vs. Guardians?

Using cutting-edge computer power and data, Dimers.com has simulated Tuesday's White Sox-Guardians MLB game 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, gives the Guardians a 58% chance of defeating the White Sox.

More: Full Betting Guide for White Sox vs. Guardians

White Sox vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+155), White Sox +1.5 (-165)
• Moneyline: Guardians -135, White Sox +125
• Total: Over/Under 7.5 (-110/-105)

Run Line, Moneyline and Over/Under

The Guardians are currently -1.5 favorites versus the White Sox, with +155 at BetMGM the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at -165.

BetMGM currently has the best moneyline odds for the Guardians at -135. That means you can risk $135 to win $100, for a total payout of $235, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the White Sox at +125, where you can put down $100 to profit $125, earning a total payout of $225, if they win.

The Over/Under for total runs scored is set at 7.5 with Caesars Sportsbook, which currently has the best odds for the Over at -110, while DraftKings Sportsbook currently has the best odds for the Under at -105.

As always, make sure you check all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 61% chance of covering the run line, while the Over/Under total of 7.5 runs is a 54% chance of going Over.

More: Live Win Probabilities for All Major Sports

Best Bets for White Sox vs. Guardians

• Run Line: Guardians -1.5 @ +155 via BetMGM
• Moneyline: Guardians @ -135 via BetMGM (58% probability)
• Total: Over 7.5 @ -110 via Caesars Sportsbook (54% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed investments with the legal sportsbooks in America.

Even though the White Sox are more likely to cover the run line, our best bet of Guardians -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

White Sox vs. Guardians Betting Guide

Use our dynamic widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Tuesday's White Sox-Guardians matchup, including pre-game predictions, best betting picks, and live updates.

Don't forget, DimersBOT updates frequently, so refresh this page for the latest betting analysis before White Sox vs. Guardians on Tuesday April 19, 2022.

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White Sox vs. Guardians 2022 Game Info

When do the Guardians play the White Sox?

• Date: Tuesday April 19, 2022
• Time: 6:10PM EDT / 3:10PM PDT
• Venue: Progressive Field

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