White Sox vs. Guardians Prediction and Odds - Apr 18, 2022

The Cleveland Guardians and Chicago White Sox are scheduled to meet in the MLB at Progressive Field on Monday, starting at 6:10PM EDT.

Shane Bieber (0-0, 2.70 ERA) will be on the bump for the Guardians, while the White Sox are going with Dallas Keuchel (1-0, 5.40 ERA).

Dimers' free betting picks for White Sox vs. Guardians, as well as game predictions and best odds, are featured in this article.

Who will win White Sox vs. Guardians?

Based on high-tech machine learning and data, Dimers.com has simulated Monday's White Sox-Guardians MLB matchup 10,000 times.

Dimers' proven predictive analytics model, DimersBOT, gives the Guardians a 57% chance of defeating the White Sox.

More: White Sox vs. Guardians Simulated 10,000 Times

White Sox vs. Guardians Odds

• Run Line: Guardians -1.5, White Sox +1.5
• Moneyline: Guardians -135, White Sox +125
• Total: Over/Under 7.5

Run Line, Moneyline and Over/Under

The Guardians are currently -1.5 favorites versus the White Sox, with +155 at BetMGM the best odds currently available.

For the underdog White Sox (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -169.

BetMGM currently has the best moneyline odds for the Guardians at -135. That means you can risk $135 to win $100, for a total payout of $235, if they get the W.

Elsewhere, DraftKings Sportsbook currently has the best moneyline odds for the White Sox at +125, where you can bet $100 to profit $125, earning a total payout of $225, if they win.

The Over/Under is set at 7.5 with BetMGM, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the White Sox (+1.5) are a 62% chance of covering the run line, while the 7.5-run Over/Under is a 54% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for White Sox vs. Guardians

• Run Line: White Sox +1.5 @ -169 via Caesars Sportsbook (62% probability)
• Moneyline: Guardians @ -135 via BetMGM (57% probability)
• Total: Over 7.5 @ -105 via BetMGM (54% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in the USA.

White Sox vs. Guardians Betting Guide

Use our interactive widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Monday's White Sox-Guardians matchup, including pre-game predictions, free picks, and live scores.

Don't forget, DimersBOT updates often, so check this page for any changes to our betting analysis ahead of White Sox vs. Guardians on Monday April 18, 2022.

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White Sox vs. Guardians 2022 Game Info

When do the Guardians play the White Sox?

• Date: Monday April 18, 2022
• Time: 6:10PM EDT / 3:10PM PDT
• Venue: Progressive Field

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Want more MLB predictions like this?

To get more MLB betting previews like you've just read for White Sox vs. Guardians, all you've gotta do is visit Dimers' MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can write the best MLB betting previews available. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.