White Sox vs. Cubs Prediction and Odds - May 4, 2022

MLB action continues on Wednesday at 7:40PM ET as the Chicago White Sox take on the Chicago Cubs at Wrigley Field.

Kyle Hendricks (1-2, 5.47 ERA) will start for the Cubs, while the White Sox will counter with Lucas Giolito (0-1, 2.57 ERA).

Dimers' best betting picks for White Sox vs. Cubs, as well as game predictions and best odds, are detailed below.

This CHI White Sox vs. CHI Cubs betting analysis is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new users.

Who will win White Sox vs. Cubs?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's White Sox-Cubs MLB game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the White Sox a 57% chance of getting the W against the Cubs.

More: Full Betting Guide for White Sox vs. Cubs

White Sox vs. Cubs Odds

• Run Line: Cubs +1.5 (-145), White Sox -1.5 (+130)
• Moneyline: Cubs +125, White Sox -140
• Total: Over/Under 7 (+105/-125)

Run Line, Moneyline and Over/Under

The Cubs are +1.5 underdogs versus the White Sox, with -145 at BetMGM the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +130.

BetMGM currently has the best moneyline odds for the Cubs at +125, which means you can bet $100 to profit $125, earning a total payout of $225, if they win.

Meanwhile, PointsBet currently has the best moneyline odds for the White Sox at -140, where you can risk $140 to win $100, for a total payout of $240, if they come out on top.

The Over/Under for total runs scored is set at 7 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, as well as the best odds for the Under at -125.

As always, check out all the online sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 57% chance of covering the run line, while the 7-run Over/Under is a 55% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for White Sox vs. Cubs

• Run Line: White Sox -1.5 @ +130 via DraftKings Sportsbook
• Moneyline: White Sox @ -140 via PointsBet (57% probability)
• Total: Over 7 @ +105 via DraftKings Sportsbook (55% probability) 🔥

Every time you see a 🔥, that means it's one of Dimers' best free picks of the day across any sport.

Dimers' best bets are based on detailed simulations and betting intelligence to help you make more informed decisions with the legal sportsbooks in America.

Even though the Cubs are more likely to cover the run line, our best bet of White Sox -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

White Sox vs. Cubs Betting Guide

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. CHI Cubs, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's White Sox-Cubs matchup, including pregame predictions, top betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this page for any changes to our betting analysis before White Sox vs. Cubs on Wednesday May 4, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

White Sox vs. Cubs 2022 Game Info

When do the Cubs play the White Sox?

• Date: Wednesday May 4, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Wrigley Field

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Want more MLB predictions like this?

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We use the power of predictive analytics to find value in the markets so we can publish the best MLB betting previews available. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds available.