White Sox vs. Cubs Prediction and Odds - May 3, 2022

The Chicago Cubs face the Chicago White Sox in MLB action at Wrigley Field on Tuesday, commencing at 7:40PM ET.

The Cubs will have Scott Effross (0-0, 1.80 ERA) start, pitting him against Michael Kopech (0-0, 1.42 ERA) for the White Sox.

Dimers' free betting picks for White Sox vs. Cubs, as well as game predictions and best odds, are featured in this article.

This CHI White Sox vs. CHI Cubs betting preview is sponsored by PointsBet, which has a great 5x $100 Risk-Free Bets offer for new users.

Who will win White Sox vs. Cubs?

Based on state-of-the-art computer power and data, Dimers.com has simulated Tuesday's White Sox-Cubs MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the White Sox a 56% chance of getting the W against the Cubs.

More: Free Betting Analysis for White Sox vs. Cubs

White Sox vs. Cubs Current Odds

• Run Line: Cubs +1.5 (-145), White Sox -1.5 (+135)
• Moneyline: Cubs +116, White Sox -135
• Total: Over/Under 6.5 (-115/+105)

Run Line, Moneyline and Over/Under

The Cubs are +1.5 underdogs versus the White Sox, with -145 at Caesars Sportsbook the best odds currently available.

For the favored White Sox (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +135.

FanDuel Sportsbook currently has the best moneyline odds for the Cubs at +116, which means you can bet $100 to profit $116, earning a total payout of $216, if they win.

Elsewhere, BetMGM currently has the best moneyline odds for the White Sox at -135, where you can risk $135 to win $100, for a total payout of $235, if they come out on top.

The Over/Under for total runs scored sits at 6.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -115, while Caesars Sportsbook currently has the best odds for the Under at +105.

As always, make sure you check all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Cubs (+1.5) are a 60% chance of covering the run line, while the Over/Under total of 6.5 runs is a 57% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for White Sox vs. Cubs

• Run Line: Cubs +1.5 @ -145 via Caesars Sportsbook (60% probability)
• Moneyline: White Sox @ -135 via BetMGM (56% probability)
• Total: Over 6.5 @ -115 via DraftKings Sportsbook (57% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in the United States.

White Sox vs. Cubs Probabilities

Use our interactive widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for CHI White Sox vs. CHI Cubs, and click or tap on See Matchup for more.

Dimers has full coverage of Tuesday's White Sox-Cubs matchup, including pregame predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for the latest betting analysis ahead of White Sox vs. Cubs on Tuesday May 3, 2022.

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White Sox vs. Cubs 2022 Game Info

When do the Cubs play the White Sox?

• Date: Tuesday May 3, 2022
• Time: 7:40PM ET / 4:40PM PT
• Venue: Wrigley Field

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Want more MLB analysis like this?

So, you liked our White Sox vs. Cubs betting predictions? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB matchup as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds against its own probabilities to find edges in the markets. This allows us to write the most reliable MLB betting previews and get the jump on the public and the sportsbooks.

It's only a click away, so why not take a look around?

Finally, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.