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Washington vs. USC prediction: USC favored to win men's college basketball matchup [12/6/2025]

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Written by Dave Garofolo

Get Washington vs USC predictions for college basketball Saturday.

Washington-USC Predictions and Game Preview.
Washington vs. USC men's college basketball prediction for Saturday, December 6, 2025.

Men's college basketball action continues on Saturday at 6:00PM ET as Washington locks horns with USC in men's college basketball action at Galen Center.

Based on the latest simulations, Dimers' advanced college basketball model predicts USC as the most likely winner of the Washington vs. USC game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Washington vs. USC prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Washington and USC 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives USC a 61% chance of beating Washington. Our predicted final score has USC winning 77-74.

According to our model, Washington (+4.5) has a 58% chance of covering the spread, while the over/under total of 154.5 points has a 53% chance of staying under.

 

Washington vs. USC odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

Bet Type Washington USC
Spread +4.5 (-105) -4.5 (-110)
Moneyline +180 -215
Total o154.5 (-105) u154.5 (-110)

All odds are correct at the time of publication and are subject to change.

Washington vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

Bet Type Pick Bet Now
Spread Washington +4.5 -105
Moneyline Washington +180
Total Under 154.5 -110

According to our men's college basketball best bets, the top play to make on this game is Washington +4.5 at the spread.

 

Washington vs. USC game-day updates and essential details

Saturday's men's college basketball action between USC and Washington at Galen Center is scheduled to begin at 6:00PM ET.

  • Who: Washington vs. USC
  • Date: Saturday, December 6, 2025
  • Time: 6:00PM ET/3:00PM PT
  • Venue: Galen Center

 

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Conclusion

We predict USC, with a 61% win probability, will likely beat Washington on Saturday.

AI and automation have enhanced this article to quickly deliver accurate Washington vs. USC insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

Note: Clicking links to our partners may earn us a referral fee. Learn about how we review products and services.

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Written by
Dave Garofolo
Content Producer

Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.

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