Washington vs. USC prediction: USC favored to win men's college basketball matchup [12/6/2025]

USC and Washington will meet in men's college basketball action at Galen Center on Saturday, with tipoff at 6:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts USC as the most likely winner of the Washington vs. USC game.

This article offers an expanded analysis of Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Washington vs. USC prediction: Who will win and cover?

Using innovative machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball game between Washington and USC 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives USC a 70% chance of defeating Washington. Our predicted final score has USC winning 79-74.

According to our model, the bookmakers have got it right, and Washington and USC each have a 50% chance of covering the spread, while the over/under total of 154.5 points also has an equal 50-50 chance of hitting.

Washington vs. USC odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Washington vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: