May 25, 2026
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Read Article Nationals vs. Guardians prediction: Why Cleveland is favored to win Monday's MLB matchup [5/25/2026]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Washington Nationals vs Cleveland Guardians predictions for MLB Monday.
MLB action continues on Monday at 6:10 PM ET as the Washington Nationals take on the Cleveland Guardians at Progressive Field.
The Guardians will start Tanner Bibee (0-6, 3.75 ERA), pitting him against Zack Littell (3-4, 5.83 ERA) for the Nationals.
Based on updated simulations, Dimers' advanced MLB model predicts the Guardians as the most likely winner of the Nationals vs. Guardians game.
This article offers an expanded analysis of Monday's matchup, including best bets and picks.
Nationals vs. Guardians prediction: Who will win and cover?
Using powerful machine learning and data, we have simulated the result of Monday's MLB game between the Nationals and Guardians, forming part of our MLB predictions coverage.
Our famous predictive model currently gives the Guardians a 61% chance of beating the Nationals.
According to our model, the Nationals (+1.5) have a 56% chance of covering the run line, while the over/under total of eight runs has a 55% chance of going over.
Nationals vs. Guardians odds [5/25/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Nationals | Guardians |
|---|---|---|
| Run Line | +1.5 (-144) | -1.5 (+122) |
| Moneyline | +148 | -174 |
| Total | o8 (-114) | u8 (-105) |
All odds are correct at the time of publication and are subject to change.
Nationals vs. Guardians picks and best bet
After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Guardians -1.5 | +122 |
| Moneyline | Nationals | +148 |
| Total | Over 8 | -114 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Nationals vs. Guardians game-day updates and essential details
Monday's MLB game between the Guardians and Nationals at Progressive Field is scheduled to commence at 6:10 PM ET.
- Who: Washington Nationals vs. Cleveland Guardians
- Date: Monday, May 25, 2026
- Time: 6:10 PM ET/3:10PM PT
- Venue: Progressive Field
Conclusion
We predict the Guardians, with a 61% win probability, will likely beat the Nationals in Monday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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