Virginia Tech vs. Duke CBB Predictions and Odds - Dec 22, 2021

Duke squares off with Virginia Tech in College Basketball action at Cameron Indoor Stadium on Wednesday, starting at 9:00PM EST.

Dimers' best betting picks for Virginia Tech vs. Duke, plus game predictions and best odds, are detailed in this article.

Who will win Virginia Tech vs. Duke?

Using advanced machine learning and data, Dimers.com has simulated Wednesday's Virginia Tech-Duke NCAA Basketball matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives Duke a 77% chance of beating Virginia Tech.

MORE: Full Betting Guide for Virginia Tech vs. Duke

Point Spread, Moneyline and Over/Under

Duke is the -9.5 favorite versus Virginia Tech, with -110 at BetMGM the best odds available.

For the underdog Virginia Tech (+9.5) to cover the spread, BetMGM also has the best odds on offer at -110.

DraftKings Sportsbook has the best moneyline odds for Duke at -425, which means you can risk $425 to win $100, for a total payout of $525, if it gets the W.

On the other hand, FanDuel Sportsbook has the best moneyline odds for Virginia Tech at +360, where you can bet $100 to profit $360, earning a total payout of $460, if it wins.

The Over/Under for total points scored sits at 138.5 with BetMGM, which has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out all the online sportsbooks that are available in your state for the best College Basketball odds and lines.

According to DimersBOT, Virginia Tech (+9.5) is a 59% chance of covering the spread, while the 138.5-point Over/Under is considered an equal 50-50 chance of hitting.

MORE: Predictions for Every College Basketball Game

Best Bets for Virginia Tech vs. Duke

• Spread: Virginia Tech +9.5 at -110 with BetMGM (59% probability) 🔥
• Moneyline: Virginia Tech Win at +360 with FanDuel Sportsbook (1.9% edge)
• Over/Under: Under 138.5 at -110 with BetMGM (50% probability)

Any time you see a 🔥, that means it's one of Dimers' best bets of the day across all sports.

While Duke is more likely to win the game, according to DimersBOT, betting on Virginia Tech moneyline is the best option because of the 1.9% edge found when comparing our data-led probabilities to the sportsbooks' odds.

Taking advantage of the edges published here at Dimers.com is one of the keys to being profitable in the long run.

Virginia Tech vs. Duke Score Prediction

Dimers.com's predicted final score for Virginia Tech vs. Duke at Cameron Indoor Stadium this Wednesday has Duke winning 73-65.

Use our interactive widget below to explore the current Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of Wednesday's Virginia Tech-Duke matchup, including pre-game predictions, free betting picks, and live updates.

Remember, DimersBOT updates frequently, so keep checking this article for any changes to our betting insights ahead of Virginia Tech vs. Duke on Wednesday December 22, 2021.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Virginia Tech vs. Duke 2021 CBB Game Info

When does Duke play Virginia Tech in College Basketball?

• Date: Wednesday December 22, 2021
• Time: 9:00PM EST / 6:00PM PST
• Venue: Cameron Indoor Stadium

Want to join an online sportsbook and start betting on College Basketball now? Check out the top sports betting sign-up offers in your state.

What other CBB games are on tonight?

Virginia Tech and Duke aren't the only two NCAA Basketball teams you can bet on today. DimersBOT never stops and we've got picks and top bets for each and every CBB matchup via our College Basketball Predictions section.

Not only do we provide with you great predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!