Vanderbilt vs. Wake Forest prediction: Why Vanderbilt is favored to win men's college basketball matchup [12/21/2025]

Wake Forest will take on the favored Vanderbilt in men's college basketball action at Lawrence Joel Veterans Memorial Coliseum on Sunday, starting at 1:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts Vanderbilt as the most likely winner of the Vanderbilt vs. Wake Forest game.

This article offers an expanded analysis of Sunday's matchup, including an expanded look at the predicted score, best bets and picks.

Vanderbilt vs. Wake Forest prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Sunday's NCAA basketball matchup between Vanderbilt and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Vanderbilt a 65% chance of beating Wake Forest. Our predicted final score has Vanderbilt winning 81-77.

According to our model, Wake Forest (+5.5) has a 58% chance of covering the spread, while the over/under total of 162.5 points has a 53% chance of staying under.

Vanderbilt vs. Wake Forest odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Vanderbilt vs. Wake Forest picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: