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Vanderbilt vs. Wake Forest prediction: Why Vanderbilt is favored to win men's college basketball matchup [12/21/2025]
Updated: | First published:
Written by Jason Bevilacqua, Head of Content and Communities
Get Vanderbilt vs Wake Forest predictions for college basketball Sunday.
Wake Forest and Vanderbilt will meet in men's college basketball action at Lawrence Joel Veterans Memorial Coliseum on Sunday, starting at 1:00 PM ET.
Based on updated simulations, Dimers' advanced college basketball model predicts Vanderbilt as the most likely winner of the Vanderbilt vs. Wake Forest game.
This article offers further insights into Sunday's matchup, including an expanded look at the predicted score, best bets and picks.
Vanderbilt vs. Wake Forest prediction: Who will win and cover?
Using powerful machine learning and statistical analysis, we have simulated the result of Sunday's NCAA basketball matchup between Vanderbilt and Wake Forest 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives Vanderbilt a 63% chance of defeating Wake Forest. Our predicted final score has Vanderbilt winning 81-77.
According to our model, Wake Forest (+6.5) has a 61% chance of covering the spread, while the 164.5-point over/under has a 55% chance of staying under.
Vanderbilt vs. Wake Forest odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | Vanderbilt | Wake Forest |
|---|---|---|
| Spread | -6.5 (-102) | +6.5 (-115) |
| Moneyline | -250 | +215 |
| Total | o164.5 (-110) | u164.5 (-110) |
All odds are correct at the time of publication and are subject to change.
Vanderbilt vs. Wake Forest picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Wake Forest +6.5 | -115 |
| Moneyline | Wake Forest | +215 |
| Total | Under 164.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is Wake Forest +6.5 at the spread.
Vanderbilt vs. Wake Forest game-day updates and essential details
Sunday's men's college basketball action between Wake Forest and Vanderbilt at Lawrence Joel Veterans Memorial Coliseum is scheduled to start at 1:00 PM ET.
- Who: Vanderbilt vs. Wake Forest
- Date: Sunday, December 21, 2025
- Time: 1:00 PM ET/10:00AM PT
- Venue: Lawrence Joel Veterans Memorial Coliseum
Conclusion
We predict Vanderbilt, with a 63% win probability, will likely beat Wake Forest on Sunday.
AI and automation have enhanced this article to quickly deliver accurate Vanderbilt vs. Wake Forest insights, with human oversight ensuring high editorial quality. Our predictions are based on the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Jason Bevilacqua, an expert in MLB, NHL, NBA, MLS, and NFL, delivers game previews, best bets, and props. Since 2020, as Head of Social and Community at Dimers, he has contributed insightful articles utilizing data-driven models and simulations.
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