UTSA vs. USC prediction: USC favored to win men's college basketball matchup [12/17/2025]

USC will take on UTSA in men's college basketball action at Galen Center on Wednesday, starting at 9:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts USC as the most likely winner of the UTSA vs. USC game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

UTSA vs. USC prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the outcome of Wednesday's NCAA basketball matchup between UTSA and USC 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives USC a 97% chance of beating UTSA. Our predicted final score has USC winning 90-65.

According to our model, USC (-23.5) has a 52% chance of covering the spread, while the 158.5-point over/under has a 52% chance of staying under.

UTSA vs. USC odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

UTSA vs. USC picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: