USC vs. San Diego prediction: USC favored to win men's college basketball matchup [12/9/2025]

San Diego and USC are scheduled to meet in men's college basketball action at Jenny Craig Pavilion on Tuesday, starting at 9:00PM ET.

Based on the latest simulations, Dimers' proven college basketball model projects USC as the most likely winner of the USC vs. San Diego game.

This article offers a closer look at Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

USC vs. San Diego prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball matchup between USC and San Diego 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives USC a 90% chance of beating San Diego. Our predicted final score has USC winning 83-69.

According to our model, San Diego (+15.5) has a 53% chance of covering the spread, while the 157.5-point over/under has a 55% chance of staying under.

USC vs. San Diego odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

USC vs. San Diego picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: