USC Upstate vs. South Carolina State prediction: USC Upstate favored to win men's college basketball matchup [12/16/2025]

South Carolina State and USC Upstate will meet in men's college basketball action at Smith-Hammond-Middleton Memorial Center on Tuesday, starting at 6:00 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model projects USC Upstate as the most likely winner of the USC Upstate vs. South Carolina State game.

This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

USC Upstate vs. South Carolina State prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Tuesday's NCAA basketball matchup between USC Upstate and South Carolina State 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives USC Upstate an 83% chance of beating South Carolina State. Our predicted final score has USC Upstate winning 79-69.

According to our model, the bookmakers have got it right, and USC Upstate and South Carolina State each have a 50% chance of covering the spread, while the over/under total of 147.5 points has a 52% chance of going over.

USC Upstate vs. South Carolina State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

USC Upstate vs. South Carolina State picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: