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USC Upstate vs. South Carolina State prediction: USC Upstate favored to win men's college basketball matchup [12/16/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get USC Upstate vs South Carolina State predictions for college basketball Tuesday.
South Carolina State will take on the favored USC Upstate in men's college basketball action at Smith-Hammond-Middleton Memorial Center on Tuesday, beginning at 6:00 PM ET.
Based on updated simulations, Dimers' proven college basketball model predicts USC Upstate as the most likely winner of the USC Upstate vs. South Carolina State game.
This article offers further insights into Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.
USC Upstate vs. South Carolina State prediction: Who will win and cover?
Using powerful machine learning and data analysis, we have simulated the outcome of Tuesday's NCAA basketball matchup between USC Upstate and South Carolina State 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model gives USC Upstate an 82% chance of defeating South Carolina State. Our predicted final score has USC Upstate winning 79-69.
According to our model, USC Upstate (-10.5) has a 51% chance of covering the spread, while the 147.5-point over/under has a 52% chance of going over.
USC Upstate vs. South Carolina State odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | USC Upstate | South Carolina State |
|---|---|---|
| Spread | -10.5 (-102) | +10.5 (-110) |
| Moneyline | -520 | +450 |
| Total | o147.5 (-110) | u147.5 (-105) |
All odds are correct at the time of publication and are subject to change.
USC Upstate vs. South Carolina State picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | USC Upstate -10.5 | -102 |
| Moneyline | South Carolina State | +450 |
| Total | Over 147.5 | -110 |
According to our men's college basketball best bets, the top play to make on this game is USC Upstate -10.5 at the spread.
USC Upstate vs. South Carolina State game-day updates and essential details
Tuesday's men's college basketball game between South Carolina State and USC Upstate at Smith-Hammond-Middleton Memorial Center is scheduled to start at 6:00 PM ET.
- Who: USC Upstate vs. South Carolina State
- Date: Tuesday, December 16, 2025
- Time: 6:00 PM ET/3:00PM PT
- Venue: Smith-Hammond-Middleton Memorial Center
Conclusion
We predict USC Upstate, with an 82% win probability, will likely beat South Carolina State on Tuesday.
AI and automation have enhanced this article to quickly deliver accurate USC Upstate vs. South Carolina State insights, with human oversight ensuring high editorial quality. Our predictions are based on up-to-date data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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