Twins vs. Royals Prediction and Odds - Apr 21, 2022

MLB action continues on Thursday at 2:10PM ET as the Minnesota Twins square off with the Kansas City Royals at Kauffman Stadium.

Zack Greinke (0-0, 2.46 ERA) will be on the bump for the Royals, pitting him against Joe Ryan (1-1, 2.70 ERA) for the Twins.

Dimers' best betting picks for Twins vs. Royals, plus game predictions and best odds, are detailed below.

Who will win Twins vs. Royals?

Based on state-of-the-art computer power and data, Dimers.com has simulated Thursday's Twins-Royals MLB game 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives the Twins a 57% chance of winning against the Royals.

More: Full Betting Analysis for Twins vs. Royals

Twins vs. Royals Game Odds

• Run Line: Royals +1.5 (-125), Twins -1.5 (+120)
• Moneyline: Royals +125, Twins -142
• Total: Over/Under 7.5 (-114/+100)

Run Line, Moneyline and Over/Under

The Royals are +1.5 underdogs against the Twins, with -125 at Caesars Sportsbook the best odds currently available.

For the favored Twins (-1.5) to cover the run line, BetMGM has the best odds currently on offer at +120.

DraftKings Sportsbook currently has the best moneyline odds for the Royals at +125, which means you can bet $100 to profit $125, earning a total payout of $225, if they win.

Meanwhile, FanDuel Sportsbook currently has the best moneyline odds for the Twins at -142, where you can risk $142 to win $100, for a total payout of $242, if they come out on top.

The Over/Under for total runs scored sits at 7.5 with FanDuel Sportsbook, which currently has the best odds for the Over at -114, while BetMGM currently has the best odds for the Under at +100.

As always, make sure you check all the online sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 56% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Twins vs. Royals

• Run Line: Royals +1.5 @ -125 via Caesars Sportsbook (56% probability)
• Moneyline: Royals @ +125 via DraftKings Sportsbook
• Total: Over 7.5 @ -114 via FanDuel Sportsbook (53% probability)

Dimers' best bets are based on complex simulations and betting intelligence to help you make smarter investments with the legal sportsbooks in your state.

While the Twins are more likely to win the game, according to DimersBOT, taking the Royals moneyline is the best option due to the edge identified when comparing our data-led probabilities to the betting odds currently available.

Taking advantage of the edges published on Dimers is crucial to achieving long-term profitability as a bettor.

Twins vs. Royals Betting Guide

Use our widget below to see the latest Moneyline, Over/Under and Run Line probabilities and odds for Minnesota vs. Kansas City, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Thursday's Twins-Royals matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so check this page for any changes to our betting analysis ahead of Twins vs. Royals on Thursday April 21, 2022.

Best Betting Promo for Twins vs. Royals

Looking for the best sportsbook promo in America for Minnesota vs. Kansas City? Join FanDuel Sportsbook now and get your first bet risk free up to $1,000, which you can use on Thursday's Twins-Royals game.

Simply click or tap on this exclusive FanDuel Sportsbook link and create an account – it's easy and takes less than 2 minutes.

Then, make your first deposit and place a bet up to $1,000 on Twins vs. Royals. If you don't win your bet, FanDuel Sportsbook will give it back to you in site credit!

This offer is available to all new FanDuel Sportsbook users – no promo code needed!

Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Twins vs. Royals 2022 Game Info

When do the Royals play the Twins?

• Date: Thursday April 21, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Kauffman Stadium

Enjoy Dimers and want to keep the site free? Every time you register and bet with a sportsbook featured here, we get paid a small fee.

These fees help us keep Dimers free for sports fans like you. So, if you like what you see, support us by joining one of our legal sports betting partners.

What MLB games are on today?

Now you've got the 411 on Twins vs. Royals, check out the latest betting predictions for all upcoming MLB games in our MLB Bet Hub, where you can find probabilities and odds, plus our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.