Tigers vs. Guardians Prediction and Odds - May 21, 2022

The Cleveland Guardians take on the Detroit Tigers in MLB action at Progressive Field on Saturday, commencing at 6:10PM ET.

The Guardians will have Shane Bieber (1-2, 3.72 ERA) start, while the Tigers are going with Alex Faedo (0-1, 2.87 ERA).

Dimers' free betting picks for Tigers vs. Guardians, plus game predictions and best odds, are featured in this article.

This Detroit vs. Cleveland betting analysis is presented by PointsBet, which has a tasty 5x $100 Risk-Free Bets offer for new users.

Who will win Tigers vs. Guardians?

Based on high-tech computer power and data, Dimers.com has simulated Saturday's Tigers-Guardians MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives the Guardians a 65% chance of getting the W against the Tigers .

More: Tigers vs. Guardians Simulated 10,000 Times

Tigers vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+118), Tigers +1.5 (-130)
• Moneyline: Guardians -185, Tigers +165
• Total: Over/Under 7.5 (-115/-104)

Run Line, Moneyline and Over/Under

The Guardians are listed as -1.5 favorites versus the Tigers, with +118 at FanDuel Sportsbook the best odds currently available.

For the underdog Tigers (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on the market at -130.

Caesars Sportsbook currently has the best moneyline odds for the Guardians at -185. That means you can risk $185 to win $100, for a total payout of $285, if they get the W.

On the other hand, Caesars Sportsbook also has the best moneyline odds for the Tigers at +165, where you can bet $100 to profit $165, earning a total payout of $265, if they win.

The Over/Under for total runs scored is set at 7.5 with PointsBet, which currently has the best odds for the Over at -115, while FanDuel Sportsbook currently has the best odds for the Under at -104.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Tigers (+1.5) are a 54% chance of covering the run line, while the Over/Under total of 7.5 runs is a 54% chance of going Over.

More: Live Scores for All Major Sports

Best Bets for Tigers vs. Guardians

• Run Line: Guardians -1.5 @ +118 via FanDuel Sportsbook (0.2% edge)
• Moneyline: Guardians @ -185 via Caesars Sportsbook (65% probability)
• Total: Over 7.5 @ -115 via PointsBet (54% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to serve you the best possible plays every day of the year.

Even though the Tigers are more likely to cover the run line, our best bet of Guardians -1.5 is based on the expectation of that happening, according to DimersBOT, and the top odds available.

Tigers vs. Guardians Probabilities

Use our dynamic widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Detroit vs. Cleveland, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Saturday's Tigers-Guardians matchup, including pregame predictions, free betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so keep checking this article for the latest betting insights before Tigers vs. Guardians on Saturday May 21, 2022.

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Tigers vs. Guardians 2022 Game Info

Saturday's game between the Guardians and Tigers at Progressive Field is scheduled to begin at 6:10PM ET.

• Date: Saturday May 21, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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Want more MLB analysis like this?

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It's only a click away, so why not take a look around?

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