Texas Tech vs. Duke prediction: Duke favored to win men's college basketball matchup [12/20/2025]

Men's college basketball action continues on Saturday at 8:00 PM ET as Texas Tech takes on Duke in men's college basketball action at Madison Square Garden.

Based on the latest simulations, Dimers' advanced college basketball model predicts Duke as the most likely winner of the Texas Tech vs. Duke game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Texas Tech vs. Duke prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA basketball matchup between Texas Tech and Duke 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Duke a 79% chance of beating Texas Tech. Our predicted final score has Duke winning 79-71.

According to our model, Duke (-8.5) has a 51% chance of covering the spread, while the 153.5-point over/under has a 53% chance of staying under.

Texas Tech vs. Duke odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Texas Tech vs. Duke picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: