Tennessee-Martin vs. Southern Illinois prediction: Southern Illinois favored to win men's college basketball matchup [12/10/2025]

Southern Illinois will face Tennessee-Martin in men's college basketball action at Banterra Center on Wednesday, commencing at 8:00PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Southern Illinois as the most likely winner of the Tennessee-Martin vs. Southern Illinois game.

This article offers a closer look at Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Tennessee-Martin vs. Southern Illinois prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Tennessee-Martin and Southern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Southern Illinois an 80% chance of defeating Tennessee-Martin. Our predicted final score has Southern Illinois winning 77-68.

According to our model, Southern Illinois (-8.5) has a 51% chance of covering the spread, while the over/under total of 147.5 points has a 52% chance of staying under.

Tennessee-Martin vs. Southern Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Tennessee-Martin vs. Southern Illinois picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: