Syracuse vs. Notre Dame CBB Predictions and Odds - Feb 23, 2022

College Basketball action continues on Wednesday at 7:00PM EST as Syracuse faces off with the favored Notre Dame at Purcell Pavilion.

Dimers' free betting picks for Syracuse vs. Notre Dame, as well as game predictions and best odds, are featured in this article.

Who will win Syracuse vs. Notre Dame?

Based on state-of-the-art machine learning and data, Dimers.com has simulated Wednesday's Syracuse-Notre Dame NCAA Basketball matchup 10,000 times.

Dimers' famous predictive analytics model, DimersBOT, currently gives Notre Dame a 67% chance of beating Syracuse.

MORE: Syracuse vs. Notre Dame Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Notre Dame is the -5.5 favorite versus Syracuse, with -110 at BetMGM the best odds currently available.

For the underdog Syracuse (+5.5) to cover the spread, BetMGM also has the best odds currently on offer at -110.

DraftKings Sportsbook currently has the best moneyline odds for Notre Dame at -210, which means you can risk $210 to win $100, for a total payout of $310, if it gets the W.

Elsewhere, BetMGM currently has the best moneyline odds for Syracuse at +195, where you can bet $100 to profit $195, earning a total payout of $295, if it wins.

The Over/Under for total points scored sits at 146 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, make sure you check all the online sportsbooks that are available in your state for the best College Basketball odds and lines.

According to DimersBOT, Syracuse (+5.5) is a 59% chance of covering the spread, while the 146-point Over/Under is a 54% chance of going Under.

MORE: Live Scores for All Major College Sports

Best Bets for Syracuse vs. Notre Dame

• Spread: Syracuse +5.5 at -110 with BetMGM (59% probability) 🔥
• Moneyline: Notre Dame at -210 with DraftKings Sportsbook (67% probability)
• Over/Under: Under 146 at -110 with PointsBet (54% probability)

Every time you see a 🔥, that means you've found one of our best bets of the day across any sport.

Dimers' best bets are based on complex simulations and wagering intelligence to help you make more informed decisions.

Syracuse vs. Notre Dame Score Prediction

Dimers.com's predicted final score for Syracuse vs. Notre Dame at Purcell Pavilion this Wednesday has Notre Dame winning 74-70.

Use our interactive widget below to explore up-to-date Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Wednesday's Syracuse-Notre Dame matchup, including pre-game predictions, top betting picks, and live win probabilities.

Remember, DimersBOT updates often, so refresh this article for the latest betting analysis ahead of Syracuse vs. Notre Dame on Wednesday February 23, 2022.

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Syracuse vs. Notre Dame 2022 CBB Game Info

When does Notre Dame play Syracuse in College Basketball?

• Date: Wednesday February 23, 2022
• Time: 7:00PM EST / 4:00PM PST
• Venue: Purcell Pavilion

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What other CBB games are on tonight?

Now you've got the 411 on Syracuse vs. Notre Dame, get the latest betting predictions for all upcoming NCAA Basketball games in Dimers' College Basketball Bet Hub. There you can find probabilities and odds, and our best bets for each and every CBB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!