Syracuse vs. Duke CBB Predictions and Odds - Jan 22, 2022

Duke and Syracuse clash in College Basketball action at Cameron Indoor Stadium on Saturday, starting at 12:00PM EST.

Dimers' best betting picks for Syracuse vs. Duke, plus game predictions and best odds, are detailed in this article.

Who will win Syracuse vs. Duke?

Based on trusted computer power and data, Dimers.com has simulated Saturday's Syracuse-Duke NCAA Basketball game 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives Duke an 81% chance of beating Syracuse.

MORE: Syracuse vs. Duke Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Duke is the -11.5 favorite against Syracuse, with -110 at PointsBet the best odds currently available.

For the underdog Syracuse (+11.5) to cover the spread, PointsBet also has the best odds currently on the market at -110.

PointsBet currently has the best moneyline odds for Duke at -670. That means you can risk $670 to win $100, for a total payout of $770, if it gets the W.

Meanwhile, BetMGM currently has the best moneyline odds for Syracuse at +500, where you can bet $100 to profit $500, earning a total payout of $600, if it wins.

The Over/Under sits at 154.5 with PointsBet, which currently has the best odds for the Over at -110, as well as the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best College Basketball odds and lines.

According to DimersBOT, Syracuse (+11.5) is a 58% chance of covering the spread, while the Over/Under total of 154.5 points is a 53% chance of going Under.

MORE: Live Win Probabilities for All Major College Sports

Best Bets for Syracuse vs. Duke

• Spread: Syracuse +11.5 at -110 with PointsBet (58% probability) 🔥
• Moneyline: Syracuse at +500 with BetMGM (2.6% edge)
• Over/Under: Under 154.5 at -110 with PointsBet (53% probability)

Any time you see a 🔥, that means you've found one of our best free picks today across all sports.

Dimers' best bets are based on detailed simulations and wagering intelligence to help you make more informed investments.

While Duke is more likely to win the game, according to DimersBOT, taking Syracuse moneyline is the best option due to the 2.6% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen here at Dimers is one of the keys to being profitable in the long run.

Syracuse vs. Duke Score Prediction

Dimers.com's predicted final score for Syracuse vs. Duke at Cameron Indoor Stadium this Saturday has Duke winning 81-71.

Use our widget below to explore up-to-date Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Saturday's Syracuse-Duke matchup, including pre-game predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so check this page for the latest betting analysis ahead of Syracuse vs. Duke on Saturday January 22, 2022.

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Syracuse vs. Duke 2022 CBB Game Info

When does Duke play Syracuse in College Basketball?

• Date: Saturday January 22, 2022
• Time: 12:00PM EST / 9:00AM PST
• Venue: Cameron Indoor Stadium

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Want more College Basketball predictions like this?

To get more NCAA Basketball betting predictions like you've just read for Syracuse vs. Duke, all you've gotta do is visit Dimers' College Basketball Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can publish the best CBB betting previews out there. We do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.