St. John's vs. Kentucky prediction: St. John's favored to win men's college basketball matchup [12/20/2025]

Kentucky will take on St. John's, in what is expected to be a tight Men's College Basketball game, at State Farm Arena on Saturday, commencing at 12:30 PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model gives St. John's a slight edge with a 54% win probability over Kentucky.

This article offers a closer look at Saturday's St. John's vs. Kentucky matchup, including an expanded look at the predicted score, best bets and picks.

St. John's vs. Kentucky prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between St. John's and Kentucky 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives St. John's a 54% chance of beating Kentucky. Our predicted final score has St. John's winning 78-77.

According to our model, Kentucky (+3.5) has a 61% chance of covering the spread, while the 154.5-point over/under has a 52% chance of staying under.

St. John's vs. Kentucky odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

St. John's vs. Kentucky picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: