Southern University vs. Illinois prediction: Why Illinois is favored to win men's college basketball matchup [12/29/2025]

Men's college basketball action continues on Monday at 3:00 PM ET as Southern University looks to defy the odds against Illinois in men's college basketball action at State Farm Center.

Based on updated simulations, Dimers' advanced college basketball model projects Illinois as the most likely winner of the Southern University vs. Illinois game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern University vs. Illinois prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Monday's NCAA basketball game between Southern University and Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Illinois a 98% chance of beating Southern University. Our predicted final score has Illinois winning 95-66.

According to our model, Southern University (+30.5) has a 53% chance of covering the spread, while the 164.5-point over/under has a 52% chance of staying under.

Southern University vs. Illinois odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern University vs. Illinois picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: