Southern Miss vs. Southern Illinois CBB Predictions and Odds - Dec 4, 2021

Southern Illinois takes on Southern Miss in College Basketball action at SIU Arena on Saturday, commencing at 9:00 PM EST.

Dimers' top betting picks for Southern Miss vs. Southern Illinois, plus game predictions and best odds, are detailed in this article.

Who will win Southern Miss vs. Southern Illinois?

Using state-of-the-art machine learning and data, Dimers.com has simulated Saturday's Southern Miss-Southern Illinois NCAA Basketball matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, gives Southern Illinois an 83% chance of defeating Southern Miss.

MORE: Southern Miss vs. Southern Illinois Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

Southern Illinois is currently the -9.5 favorite versus Southern Miss, with -110 at BetMGM the best odds available.

For the underdog Southern Miss (+9.5) to cover the spread, FanDuel Sportsbook has the best odds on the market at -104.

DraftKings Sportsbook has the best moneyline odds for Southern Illinois at -510, which means you can risk $510 to win $100, for a total payout of $610, if it gets the W.

Meanwhile, FanDuel Sportsbook has the best moneyline odds for Southern Miss at +430, where you can put down $100 to profit $430, earning a total payout of $530, if it wins.

The Over/Under sits at 127 with DraftKings Sportsbook, which has the best odds for the Over at +100, as well as the best odds for the Under at -120.

As always, check out the sportsbooks you can bet with in your state for the best College Basketball odds and lines.

According to DimersBOT, Southern Miss (+9.5) is a 56% chance of covering the spread, while the Over/Under total of 127 points is a 53% chance of going Over.

MORE: Predictions for Every College Basketball Game

Best Bets for Southern Miss vs. Southern Illinois

• Spread: Southern Miss +9.5 at -104 with FanDuel Sportsbook (56% probability) 🔥
• Moneyline: Southern Illinois Win at -510 with DraftKings Sportsbook (83% probability)
• Over/Under: Over 127 at +100 with DraftKings Sportsbook (53% probability)

Any time you see a 🔥, that means it's one of our best bets today across all major pro and college sports.

Southern Miss vs. Southern Illinois Score Prediction

Dimers.com's predicted final score for Southern Miss vs. Southern Illinois at SIU Arena this Saturday has Southern Illinois winning 67-59.

Use our dynamic widget below to view the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Southern Miss-Southern Illinois matchup, including pre-game predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so check this article for any changes to our betting analysis ahead of Southern Miss vs. Southern Illinois on Saturday December 4, 2021.

Southern Miss vs. Southern Illinois 2021 CBB Game Info

When does Southern Illinois play Southern Miss in College Basketball?

• Date: Saturday December 4, 2021
• Time: 9:00 PM EST / 6:00 PM PST
• Venue: SIU Arena

Want to join an online sportsbook and start betting on College Basketball now? We've reviewed the best available sign-up offers for each and every legal betting state.

What other College Basketball games are on tonight?

Now you've got the 411 on Southern Miss vs. Southern Illinois, take a look at the latest betting coverage for all upcoming NCAA Basketball games in our College Basketball Bet Hub, where you can find probabilities and odds, plus our best bets for every single CBB matchup.

Want a pick for the Spread? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!