Southern Miss vs. Ole Miss prediction: Ole Miss favored to win men's college basketball matchup [12/13/2025]

Ole Miss and Southern Miss will lock horns in men's college basketball action at Mississippi Coast Coliseum on Saturday, starting at 3:00PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model projects Ole Miss as the most likely winner of the Southern Miss vs. Ole Miss game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Miss vs. Ole Miss prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Saturday's NCAA basketball matchup between Southern Miss and Ole Miss 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Ole Miss a 92% chance of beating Southern Miss. Our predicted final score has Ole Miss winning 76-62.

According to our model, Ole Miss (-13.5) has a 53% chance of covering the spread, while the over/under total of 137.5 points has a 53% chance of going over.

Southern Miss vs. Ole Miss odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Miss vs. Ole Miss picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: