Southern Miss vs. LSU prediction: LSU favored to win men's college basketball matchup [12/29/2025]

LSU will face Southern Miss in men's college basketball action at Pete Maravich Assembly Center on Monday, starting at 8:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts LSU as the most likely winner of the Southern Miss vs. LSU game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Miss vs. LSU prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Monday's NCAA basketball game between Southern Miss and LSU 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives LSU a 95% chance of defeating Southern Miss. Our predicted final score has LSU winning 88-68.

According to our model, the bookmakers have got it right, and Southern Miss and LSU each have a 50% chance of covering the spread, while the over/under total of 156.5 points has a 52% chance of going over.

Southern Miss vs. LSU odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Miss vs. LSU picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: