Southern Indiana vs. SIUE prediction: SIU-Edwardsville favored to win men's college basketball matchup [1/1/2026]

SIUE will face Southern Indiana in men's college basketball action at Sam M. Vadalabene Center on New Year's Day, beginning at 4:30 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts SIU-Edwardsville as the most likely winner of the Southern Indiana vs. SIUE game.

This article offers further insights into Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Indiana vs. SIUE prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Thursday's NCAA basketball matchup between Southern Indiana and SIUE 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives SIU-Edwardsville an 87% chance of beating Southern Indiana. Our predicted final score has SIU-Edwardsville winning 75-64.

According to our model, SIU-Edwardsville (-10.5) has a 56% chance of covering the spread, while the over/under total of 139.5 points has an equal 50-50 chance of hitting.

Southern Indiana vs. SIUE odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Indiana vs. SIUE picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: