Southern Illinois vs. San Francisco CBB Predictions and Odds - Dec 22, 2021

College Basketball action continues on Wednesday at 5:00PM EST as Southern Illinois faces off with the favored San Francisco at War Memorial Gymnasium.

Dimers' free betting picks for Southern Illinois vs. San Francisco, as well as game predictions and best odds, are featured below.

Who will win Southern Illinois vs. San Francisco?

Based on state-of-the-art computer power and data, Dimers.com has simulated Wednesday's Southern Illinois-San Francisco NCAA Basketball matchup 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, gives San Francisco an 81% chance of beating Southern Illinois.

MORE: Southern Illinois vs. San Francisco Simulated 10,000 Times

Point Spread, Moneyline and Over/Under

San Francisco is the -9.5 favorite against Southern Illinois, with -110 at BetMGM the best odds available.

For the underdog Southern Illinois (+9.5) to cover the spread, BetMGM also has the best odds on offer at -110.

PointsBet has the best moneyline odds for San Francisco at -500, which means you can risk $500 to win $100, for a total payout of $600, if it gets the W.

Meanwhile, DraftKings Sportsbook has the best moneyline odds for Southern Illinois at +425, where you can bet $100 to profit $425, earning a total payout of $525, if it wins.

The Over/Under sits at 124 with DraftKings Sportsbook, which has the best odds for the Over at -105, while PointsBet has the best odds for the Under at -110.

As always, make sure you check all the legal sportbooks that are available in your state for the best College Basketball odds and lines.

According to DimersBOT, Southern Illinois (+9.5) is a 59% chance of covering the spread, while the Over/Under total of 124 points is a 52% chance of going Over.

MORE: Predictions for Every College Basketball Game

Best Bets for Southern Illinois vs. San Francisco

• Spread: Southern Illinois +9.5 at -110 with BetMGM (59% probability) 🔥
• Moneyline: San Francisco Win at -500 with PointsBet (81% probability)
• Over/Under: Over 124 at -105 with DraftKings Sportsbook (52% probability)

Every time you see a 🔥, that means you've found one of Dimers' best free picks today across all major pro and college sports.

Southern Illinois vs. San Francisco Score Prediction

Dimers.com's predicted final score for Southern Illinois vs. San Francisco at War Memorial Gymnasium on Wednesday has San Francisco prevailing 65-58.

Use our dynamic widget below to explore the latest Spread, Over/Under and Moneyline probabilities and odds for the game, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Southern Illinois-San Francisco matchup, including pre-game predictions, free picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so refresh this page for any changes to our betting analysis ahead of Southern Illinois vs. San Francisco on Wednesday December 22, 2021.

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Southern Illinois vs. San Francisco 2021 CBB Game Info

When does San Francisco play Southern Illinois in College Basketball?

• Date: Wednesday December 22, 2021
• Time: 5:00PM EST / 2:00PM PST
• Venue: War Memorial Gymnasium

Looking to join an online sportsbook and start betting on College Basketball now? Check out the best sportsbook sign-up offers in your state.

Want more College Basketball previews like this?

To get more NCAA Basketball betting predictions like you've just read for Southern Illinois vs. San Francisco, all you've gotta do is visit Dimers' College Basketball Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find value in the markets so we can produce the best CBB betting previews out there. We're able to do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) as soon as they go live.

So, get ahead of the game and beat the 'books today – it's only a click away.