Southern Illinois vs. Murray State prediction: Why Murray State is favored to win men's college basketball matchup [12/29/2025]

Murray State will square off with Southern Illinois in men's college basketball action at CFSB Center on Monday, starting at 7:00 PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts Murray State as the most likely winner of the Southern Illinois vs. Murray State game.

This article offers further insights into Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Southern Illinois vs. Murray State prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Monday's NCAA basketball matchup between Southern Illinois and Murray State 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Murray State a 72% chance of defeating Southern Illinois. Our predicted final score has Murray State winning 84-77.

According to our model, the bookmakers have got it right, and Southern Illinois and Murray State each have a 50% chance of covering the spread, while the over/under total of 165.5 points has a 53% chance of staying under.

Southern Illinois vs. Murray State odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Southern Illinois vs. Murray State picks and best bet

After matching our probabilities against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: