USF vs. Alabama prediction: Why Alabama is favored to win men's college basketball matchup [12/17/2025]

Men's college basketball action continues on Wednesday at 8:00 PM ET as USF squares off with Alabama in men's college basketball action at Coleman Coliseum.

Based on updated simulations, Dimers' proven college basketball model predicts Alabama as the most likely winner of the USF vs. Alabama game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

USF vs. Alabama prediction: Who will win and cover?

Using powerful machine learning and data analysis, we have simulated the result of Wednesday's NCAA basketball matchup between USF and Alabama 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Alabama an 88% chance of beating South Florida. Our predicted final score has Alabama winning 91-77.

According to our model, Alabama (-14.5) has a 53% chance of covering the spread, while the over/under total of 180.5 points has a 54% chance of staying under.

USF vs. Alabama odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

USF vs. Alabama picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: