South Carolina State vs. South Carolina prediction: South Carolina favored to win men's college basketball matchup [12/22/2025]

Men's college basketball action continues on Monday at 4:00 PM ET as South Carolina State faces off with the favored South Carolina in men's college basketball action at Colonial Life Arena.

Based on the latest simulation results, Dimers' proven college basketball model predicts South Carolina as the most likely winner of the South Carolina State vs. South Carolina game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

South Carolina State vs. South Carolina prediction: Who will win and cover?

Using trusted machine learning and statistical analysis, we have simulated the result of Monday's NCAA basketball matchup between South Carolina State and South Carolina 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives South Carolina a 99% chance of defeating South Carolina State. Our predicted final score has South Carolina winning 89-60.

According to our model, South Carolina State (+31.5) has a 54% chance of covering the spread, while the over/under total of 149.5 points has a 52% chance of going over.

South Carolina State vs. South Carolina odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Carolina State vs. South Carolina picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: