South Alabama vs. Louisiana-Lafayette prediction: South Alabama favored to win men's college basketball matchup [12/31/2025]

Louisiana-Lafayette will take on South Alabama in men's college basketball action at Cajundome on Wednesday, beginning at 1:00 PM ET.

Based on the latest simulations, Dimers' advanced college basketball model predicts South Alabama as the most likely winner of the South Alabama vs. Louisiana-Lafayette game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

South Alabama vs. Louisiana-Lafayette prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between South Alabama and Louisiana-Lafayette 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives South Alabama a 63% chance of defeating Louisiana-Lafayette. Our predicted final score has South Alabama winning 66-63.

According to our model, Louisiana-Lafayette (+3.5) has a 51% chance of covering the spread, while the 127.5-point over/under has a 53% chance of going over.

South Alabama vs. Louisiana-Lafayette odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

South Alabama vs. Louisiana-Lafayette picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: