SMU vs. LSU prediction: SMU favored to win men's college basketball matchup [12/13/2025]

LSU and SMU will lock horns in men's college basketball action at Smoothie King Center on Saturday, with tipoff at 8:30PM ET.

Based on the latest simulation results, Dimers' proven college basketball model predicts SMU as the most likely winner of the SMU vs. LSU game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

SMU vs. LSU prediction: Who will win and cover?

Using innovative machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between SMU and LSU 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives SMU a 55% chance of defeating LSU. Our predicted final score has SMU winning 80-78.

According to our model, the bookmakers have got it right, and SMU and LSU each have a 50% chance of covering the spread, while the over/under total of 158.5 points has a 51% chance of staying under.

SMU vs. LSU odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

SMU vs. LSU picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: