SIUE vs. Eastern Illinois prediction: Why SIU-Edwardsville is favored to win men's college basketball matchup [12/18/2025]

Men's college basketball action continues on Thursday at 6:30 PM ET as the favored SIUE squares off with Eastern Illinois in men's college basketball action at Lantz Arena.

Based on the latest simulations, Dimers' proven college basketball model predicts SIU-Edwardsville as the most likely winner of the SIUE vs. Eastern Illinois game.

This article offers a closer look at Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

SIUE vs. Eastern Illinois prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the result of Thursday's NCAA basketball matchup between SIUE and Eastern Illinois 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives SIU-Edwardsville an 82% chance of beating Eastern Illinois. Our predicted final score has SIU-Edwardsville winning 73-64.

According to our model, SIU-Edwardsville (-6.5) has a 60% chance of covering the spread, while the over/under total of 135.5 points has a 54% chance of going over.

SIUE vs. Eastern Illinois odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

SIUE vs. Eastern Illinois picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: