Siena vs. Indiana prediction: Why Indiana is favored to win men's college basketball matchup [12/22/2025]

Indiana will face Siena in men's college basketball action at Simon Skjodt Assembly Hall on Monday, starting at 6:00 PM ET.

Based on updated simulations, Dimers' proven college basketball model predicts Indiana as the most likely winner of the Siena vs. Indiana game.

This article offers an expanded analysis of Monday's matchup, including an expanded look at the predicted score, best bets and picks.

Siena vs. Indiana prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Monday's NCAA basketball game between Siena and Indiana 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives Indiana a 98% chance of beating Siena. Our predicted final score has Indiana winning 84-61.

According to our model, the bookmakers have got it right, and Siena and Indiana each have a 50% chance of covering the spread, while the over/under total of 143.5 points has a 54% chance of going over.

Siena vs. Indiana odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Siena vs. Indiana picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: