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Mariners vs. Cardinals prediction: Seattle favored to win Friday's MLB matchup [4/24/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Seattle Mariners vs St. Louis Cardinals predictions for MLB Friday.
The St. Louis Cardinals will square off with the Seattle Mariners in MLB action at Busch Stadium on Friday, starting at 8:15 PM ET.
The Cardinals will send Andre Pallante (2-1, 4.05 ERA) to the mound, pitting him against George Kirby (3-2, 2.97 ERA) for the Mariners.
Based on the latest simulation results, Dimers' advanced MLB model predicts the Mariners as the most likely winner of the Mariners vs. Cardinals game.
This article offers further insights into Friday's matchup, including best bets and picks.
Mariners vs. Cardinals prediction: Who will win and cover?
Using innovative machine learning and data, we have simulated the outcome of Friday's MLB matchup between the Mariners and Cardinals, forming part of our MLB predictions coverage.
Our famous predictive model gives the Mariners a 57% chance of beating the Cardinals.
According to our model, the Cardinals (+1.5) have a 56% chance of covering the run line, while the 8-run over/under has a 53% chance of going over.
Mariners vs. Cardinals odds [4/24/2026]
We have researched the best MLB odds in America for this game, which are listed here:
| Bet Type | Mariners | Cardinals |
|---|---|---|
| Run Line | -1.5 (+115) | +1.5 (-135) |
| Moneyline | -146 | +125 |
| Total | o8 (-108) | u8 (-110) |
All odds are correct at the time of publication and are subject to change.
Mariners vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Run Line | Cardinals +1.5 | -135 |
| Moneyline | Cardinals | +125 |
| Total | Over 8 | -108 |
According to our MLB best bets, the top play to make on this game is Over 8 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Mariners vs. Cardinals game-day updates and essential details
Friday's MLB game between the Cardinals and Mariners at Busch Stadium is scheduled to start at 8:15 PM ET.
- Who: Seattle Mariners vs. St. Louis Cardinals
- Date: Friday, April 24, 2026
- Time: 8:15 PM ET/5:15PM PT
- Venue: Busch Stadium
Conclusion
We predict the Mariners, with a 57% win probability, will likely beat the Cardinals in Friday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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