Santa Clara vs. Portland prediction: Why Santa Clara is favored to win men's college basketball matchup [12/30/2025]

Portland and Santa Clara will lock horns in men's college basketball action at Chiles Center on Tuesday, starting at 10:00 PM ET.

Based on the latest simulations, Dimers' proven college basketball model predicts Santa Clara as the most likely winner of the Santa Clara vs. Portland game.

This article offers an expanded analysis of Tuesday's matchup, including an expanded look at the predicted score, best bets and picks.

Santa Clara vs. Portland prediction: Who will win and cover?

Using innovative machine learning and statistical analysis, we have simulated the outcome of Tuesday's NCAA basketball game between Santa Clara and Portland 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Santa Clara an 87% chance of defeating Portland. Our predicted final score has Santa Clara winning 84-71.

According to our model, Portland (+13.5) has a 53% chance of covering the spread, while the over/under total of 156.5 points has a 51% chance of staying under.

Santa Clara vs. Portland odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Santa Clara vs. Portland picks and best bet

After matching our probabilities against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: