Santa Clara vs. New Mexico prediction: Santa Clara favored to win men's college basketball matchup [12/6/2025]

New Mexico will face Santa Clara, in what is expected to be a close Men's College Basketball game, at The Pit on Saturday, starting at 9:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model gives Santa Clara a slight edge with a 51% win probability over New Mexico.

This article offers an expanded analysis of Saturday's Santa Clara vs. New Mexico matchup, including an expanded look at the predicted score, best bets and picks.

Santa Clara vs. New Mexico prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Saturday's NCAA basketball game between Santa Clara and New Mexico 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Santa Clara a 51% chance of defeating New Mexico. Our predicted final score has Santa Clara winning 76-75.

According to our model, New Mexico (+1.5) has a 55% chance of covering the spread, while the 154.5-point over/under has a 54% chance of staying under.

Santa Clara vs. New Mexico odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Santa Clara vs. New Mexico picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: