Santa Clara vs. Arizona State prediction: Why Santa Clara is favored to win men's college basketball matchup [12/13/2025]

Men's college basketball action continues on Saturday at 7:00PM ET as Santa Clara squares off with Arizona State in men's college basketball action at Lee's Family Forum.

Based on the latest simulations, Dimers' advanced college basketball model gives Santa Clara a slight edge with a 54% win probability over Arizona State.

This article offers an expanded analysis of Saturday's Santa Clara vs. Arizona State matchup, including an expanded look at the predicted score, best bets and picks.

Santa Clara vs. Arizona State prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the outcome of Saturday's NCAA basketball game between Santa Clara and Arizona State 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model gives Santa Clara a 54% chance of defeating Arizona State. Our predicted final score has Santa Clara winning 79-78.

According to our model, Arizona State (+1.5) has a 55% chance of covering the spread, while the over/under total of 156.5 points has a 51% chance of staying under.

Santa Clara vs. Arizona State odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Santa Clara vs. Arizona State picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: