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San Francisco vs. Saint Louis prediction: Saint Louis favored to win men's college basketball matchup [12/13/2025]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get San Francisco vs Saint Louis predictions for college basketball Saturday.
Saint Louis and San Francisco will meet in men's college basketball action at Chaifetz Arena on Saturday, starting at 8:00PM ET.
Based on the latest simulations, Dimers' proven college basketball model predicts Saint Louis as the most likely winner of the San Francisco vs. Saint Louis game.
This article offers a closer look at Saturday's matchup, including an expanded look at the predicted score, best bets and picks.
San Francisco vs. Saint Louis prediction: Who will win and cover?
Using trusted machine learning and data analysis, we have simulated the result of Saturday's NCAA basketball matchup between San Francisco and Saint Louis 10,000 times as part of our men's college basketball predictions coverage.
Our famous predictive model currently gives Saint Louis a 90% chance of defeating San Francisco. Our predicted final score has Saint Louis winning 83-69.
According to our model, Saint Louis (-12.5) has a 56% chance of covering the spread, while the over/under total of 154.5 points has a 53% chance of staying under.
San Francisco vs. Saint Louis odds
We have researched the best men's college basketball odds in America for this game, which are listed here:
| Bet Type | San Francisco | Saint Louis |
|---|---|---|
| Spread | +12.5 (-105) | -12.5 (-110) |
| Moneyline | +680 | -900 |
| Total | o154.5 (-115) | u154.5 (-105) |
All odds are correct at the time of publication and are subject to change.
San Francisco vs. Saint Louis picks and best bet
After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Spread | Saint Louis -12.5 | -110 |
| Moneyline | Saint Louis | -900 |
| Total | Under 154.5 | -105 |
According to our best men's college basketball bets, the top play to make on this game is Saint Louis -12.5 at the spread.
San Francisco vs. Saint Louis game-day updates and essential details
Saturday's men's college basketball action between Saint Louis and San Francisco at Chaifetz Arena is scheduled to begin at 8:00PM ET.
- Who: San Francisco vs. Saint Louis
- Date: Saturday, December 13, 2025
- Time: 8:00PM ET/5:00PM PT
- Venue: Chaifetz Arena
Conclusion
We predict Saint Louis, with a 90% win probability, will likely beat San Francisco on Saturday.
AI and automation have enhanced this article to quickly deliver accurate San Francisco vs. Saint Louis insights, with human oversight ensuring high editorial quality. Our predictions are sourced from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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