San Francisco vs. Saint Louis prediction: Saint Louis favored to win men's college basketball matchup [12/13/2025]

Saint Louis will take on San Francisco in men's college basketball action at Chaifetz Arena on Saturday, commencing at 8:00PM ET.

Based on the latest simulation results, Dimers' advanced college basketball model predicts Saint Louis as the most likely winner of the San Francisco vs. Saint Louis game.

This article offers further insights into Saturday's matchup, including an expanded look at the predicted score, best bets and picks.

San Francisco vs. Saint Louis prediction: Who will win and cover?

Using trusted machine learning and data analysis, we have simulated the outcome of Saturday's NCAA basketball game between San Francisco and Saint Louis 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Saint Louis an 88% chance of defeating San Francisco. Our predicted final score has Saint Louis winning 82-69.

According to our model, Saint Louis (-11.5) has a 54% chance of covering the spread, while the 153.5-point over/under has a 53% chance of staying under.

San Francisco vs. Saint Louis odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

San Francisco vs. Saint Louis picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: