San Diego Padres vs. Chicago Cubs Prediction, Odds, MLB Picks [5/8/2024]

San Diego Padres vs. Chicago Cubs Prediction, Odds, MLB Picks [5/8/2024]

The Chicago Cubs and San Diego Padres will meet in MLB action at Wrigley Field on Wednesday, starting at 2:20PM ET.

The Cubs will start Hayden Wesneski (2-0, 0.54 ERA), while the Padres have opted for Dylan Cease (4-2, 2.55 ERA).'s full preview of Wednesday's Padres vs. Cubs matchup includes our prediction, picks and the latest betting odds.

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Padres vs. Cubs Prediction: Who Will Win, Cover the Run Line

We have used advanced machine learning and data analysis to simulate the result of Wednesday's MLB matchup between the Padres and Cubs 10,000 times, in line with our coverage of MLB predictions.

Our proven predictive analytics model currently gives the Padres a 53% chance of beating the Cubs.

According to our model, the Cubs (+1.5) have a 60% chance of covering the run line, while the 7.5-run over/under has a 51% chance of going over.

Padres vs. Cubs Odds [5/8/2024]

We have sourced the best betting odds in America for this game, which are listed here:

Bet Type Padres Cubs
Run Line -1.5 (+135) +1.5 (-155)
Moneyline -134 +115
Total o7.5 (+100) u7.5 (-115)

All odds are correct at the time of publication and are subject to change.

Padres vs. Cubs Picks

At Dimers, our predictions, paired with the latest odds, reveal the top betting picks for every game, including Padres vs. Cubs. Our best MLB bets are based on expert modeling and analysis, as you can see.

Dimers Pro unlocks +EV bets daily. Dimers Pro subscribers get hundreds of data-driven bets daily across thousands of games. Join now to get instant access and see any potential picks for this matchup.


Padres vs. Cubs Game Information

Wednesday's MLB matchup between the Cubs and Padres at Wrigley Field is scheduled to begin at 2:20PM ET.


Our full coverage of the Padres vs. Cubs includes pregame predictions, betting picks and live win probabilities.

Calling Our Shot: Free ⚾️ Picks

Calling Our Shot produces daily MLB betting content, including the predictions featured below.


We predict the Padres, with a 53% win probability, will likely beat the Cubs on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Padres vs. Cubs insights, with human oversight ensuring high editorial quality. Our predictions are drawn from current data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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Dave Garofolo
Content Producer

Dave Garofolo, a seasoned fantasy sports and betting enthusiast with a special affection for MLB and NFL, uses his deep knowledge to craft game previews for the NBA, MLB, and NFL. He also brings his expertise to the golf world with tournament previews and parlays for the PGA TOUR and major golf tournaments. Additionally, Dave offers valuable props for NBA, MLB, NHL, and NCAAM basketball, along with best bets for MLB, NHL, and NCAAM. 

When not delving into the world of sports, Dave is an avid advocate for New Haven pizza, enjoys reading comic books, gardening, and spending time with his cats. His broad interests and detailed sports insights ensure that his contributions are both engaging and informative.

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