Samford vs. VCU prediction: Virginia Commonwealth favored to win men's college basketball matchup [12/5/2025]

VCU will face Samford in men's college basketball action at Stuart C. Siegel Center on Friday, starting at 7:00PM ET.

Based on updated simulations, Dimers' advanced college basketball model predicts Virginia Commonwealth as the most likely winner of the Samford vs. VCU game.

This article offers further insights into Friday's matchup, including an expanded look at the predicted score, best bets and picks.

Samford vs. VCU prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Friday's NCAA basketball matchup between Samford and VCU 10,000 times as part of our men's college basketball predictions coverage.

Our famous predictive model currently gives Virginia Commonwealth a 97% chance of beating Samford. Our predicted final score has Virginia Commonwealth winning 86-64.

According to our model, Virginia Commonwealth (-20.5) has a 54% chance of covering the spread, while the 151.5-point over/under has an equal 50-50 chance of hitting.

Samford vs. VCU odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Samford vs. VCU picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: