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Saints vs. 49ers Week 12 Prediction and Odds - Nov 27, 2022

The San Francisco 49ers and New Orleans Saints meet in Week 12 of the NFL season at Levi's Stadium on Sunday, with kickoff at 4:25PM ET.

Dimers' free betting picks for Saints vs. 49ers, as well as game predictions, betting odds and projected player stats, are featured in this article.


Who will win Saints vs. 49ers?

Based on cutting-edge machine learning and data, Dimers.com has simulated Sunday's Saints-49ers NFL game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the 49ers an 80% chance of winning against the Saints in Week 12 of the NFL season.

More: Free Betting Guide for Saints vs. 49ers

Saints vs. 49ers Week 12 Odds

  • Spread: 49ers -8.5 (-105), Saints +8.5 (-105)
  • Moneyline: 49ers -375, Saints +333
  • Total: Over/Under 43.5 (-105/-110)

Point Spread, Moneyline and Over/Under

The 49ers are currently -8.5 favorites against the Saints, with -105 at FanDuel Sportsbook the best odds currently available.

For the underdog Saints (+8.5) to cover the spread, PointsBet has the best odds currently on offer at -105.

FanDuel Sportsbook currently has the best moneyline odds for the 49ers at -375, which means you can risk $375 to win $100, for a total payout of $475, if they get the W.

Elsewhere, BetMGM currently has the best moneyline odds for the Saints at +333, where you can bet $100 to profit $333, earning a total payout of $433, if they win.

The Over/Under for total points scored sits at 43.5 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, make sure you check the sportsbooks you have access to in your state for the best NFL odds and lines.

According to DimersBOT, the 49ers (-8.5) are a 51% chance of covering the spread, while the Over/Under total of 43.5 points is considered an equal 50-50 chance of hitting.

More: Track Your Bets via Dimers' Bet Center

Best Bets for Saints vs. 49ers


Dimers' best bets are based on detailed simulations and gambling intelligence to help you make more informed decisions with your state's legal sportsbooks.

Saints vs. 49ers Prediction

Dimers.com's predicted final score for New Orleans vs. San Francisco at Levi's Stadium in Week 12 has the 49ers winning 26-17.

Click or tap on See Matchup to reveal more.


Dimers has full coverage of this week's Saints-49ers matchup in Week 12, including pregame predictions, computer picks, and live win probabilities.

Saints vs. 49ers Player Props

Who will score the first touchdown in Saints vs. 49ers? The data is in.

Featured below are the most likely first touchdown and most likely anytime touchdown scorers for both the Saints and 49ers, as well as player stat projections.

And you know what, we provide this information to you for FREE to help you discover the best prop picks for Sunday's game.

According to DimersBOT, San Francisco's Christian McCaffrey is most likely to score the first TD in Saints vs. 49ers.

DimersBOT gives McCaffrey a 13.4% chance of scoring the first TD at Levi's Stadium, while the 49ers RB is a 51.8% chance of scoring an anytime touchdown.

Scroll down for the full list of first and anytime TD scorer probabilities.


First Touchdown Scorer Probabilities

New Orleans Saints

  • Alvin Kamara: 9.2% probability
  • Taysom Hill: 6.6% probability
  • Chris Olave: 6.3% probability
  • Juwan Johnson: 5.0% probability
  • Jarvis Landry: 3.9% probability

San Francisco 49ers

  • Christian McCaffrey: 13.4% probability
  • Deebo Samuel: 8.2% probability
  • Elijah Mitchell: 7.8% probability
  • Brandon Aiyuk: 7.5% probability
  • George Kittle: 7.0% probability

Anytime Touchdown Scorer Probabilities

New Orleans Saints

  • Alvin Kamara: 38.9% probability
  • Taysom Hill: 30.8% probability
  • Chris Olave: 28.0% probability
  • Juwan Johnson: 24.0% probability
  • Jarvis Landry: 18.3% probability

San Francisco 49ers

  • Christian McCaffrey: 51.8% probability
  • Deebo Samuel: 35.9% probability
  • Elijah Mitchell: 33.2% probability
  • Brandon Aiyuk: 32.0% probability
  • George Kittle: 29.9% probability

Saints-49ers Projected Player Stats

Of the starting quarterbacks, the Saints' Andy Dalton is projected for 239 passing yards. The 49ers' Jimmy Garoppolo is expected to throw for 247 yards.

Saints Starting QB

  • Andy Dalton: 239 projected yards

49ers Starting QB

  • Jimmy Garoppolo: 247 projected yards

Saints Rushing

  • Alvin Kamara: 53 projected yards
  • Taysom Hill: 18 projected yards
  • Mark Ingram: 16 projected yards

49ers Rushing

  • Christian McCaffrey: 59 projected yards
  • Elijah Mitchell: 46 projected yards
  • Deebo Samuel: 21 projected yards

Saints Receiving

  • Chris Olave: 59 projected yards
  • Jarvis Landry: 44 projected yards
  • Alvin Kamara: 37 projected yards
  • Juwan Johnson: 30 projected yards
  • Adam Trautman: 17 projected yards

49ers Receiving

  • Brandon Aiyuk: 66 projected yards
  • George Kittle: 55 projected yards
  • Deebo Samuel: 49 projected yards
  • Christian McCaffrey: 43 projected yards
  • Jauan Jennings: 26 projected yards

Don't forget, DimersBOT updates often, so keep an eye on this article for any changes to our betting analysis ahead of Saints vs. 49ers on Sunday November 27, 2022.


Saints vs. 49ers 2022

The NFL Week 12 game between the 49ers and Saints at Levi's Stadium is scheduled to begin at 4:25PM ET.

  • Who: New Orleans Saints vs. San Francisco 49ers
  • Date: Sunday November 27, 2022
  • Time: 4:25PM ET / 1:25PM PT
  • Venue: Levi's Stadium

Looking to join an online sportsbook and start betting on the NFL? Check out the best sportsbook offers in your state.

What NFL games are on today?

The Saints and 49ers aren't the only two NFL teams you can bet on today. DimersBOT never stops and we've got picks and best bets for every single NFL game via our NFL Predictions section.

Not only do we provide with you quality predictions, but we also have recommended bets for the Spread, Over/Under and Moneyline. Sound good? Hell yeah it does!

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