Saint Joseph's (PA) vs. Syracuse prediction: Syracuse favored to win men's college basketball matchup [12/11/2025]

Syracuse and Saint Joseph's (PA) will lock horns in men's college basketball action at JMA Wireless Dome on Thursday, starting at 9:00PM ET.

Based on updated simulation results, Dimers' proven college basketball model predicts Syracuse as the most likely winner of the Saint Joseph's (PA) vs. Syracuse game.

This article offers further insights into Thursday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Joseph's (PA) vs. Syracuse prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Thursday's NCAA basketball matchup between Saint Joseph's (PA) and Syracuse 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model gives Syracuse an 88% chance of beating Saint Joseph's (PA). Our predicted final score has Syracuse winning 78-66.

According to our model, Saint Joseph's (PA) (+13.5) has a 53% chance of covering the spread, while the over/under total of 143.5 points has a 52% chance of going over.

Saint Joseph's (PA) vs. Syracuse odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Joseph's (PA) vs. Syracuse picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: