Saint Joseph's (PA) vs. Saint Louis prediction: Saint Louis favored to win men's college basketball matchup [12/31/2025]

Men's college basketball action continues on Wednesday at 4:00 PM ET as Saint Joseph's (PA) faces off with the favored Saint Louis in men's college basketball action at Chaifetz Arena.

Based on updated simulations, Dimers' proven college basketball model predicts Saint Louis as the most likely winner of the Saint Joseph's (PA) vs. Saint Louis game.

This article offers further insights into Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Saint Joseph's (PA) vs. Saint Louis prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's NCAA basketball matchup between Saint Joseph's (PA) and Saint Louis 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Saint Louis a 96% chance of defeating Saint Joseph's (PA). Our predicted final score has Saint Louis winning 90-68.

According to our model, Saint Louis (-19.5) has a 54% chance of covering the spread, while the over/under total of 158.5 points has a 51% chance of staying under.

Saint Joseph's (PA) vs. Saint Louis odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Saint Joseph's (PA) vs. Saint Louis picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: