Royals vs. White Sox Prediction and Odds - Apr 27, 2022

The Chicago White Sox face the Kansas City Royals in MLB action at Guaranteed Rate Field on Wednesday, beginning at 2:10PM ET.

The White Sox will have Dylan Cease (2-1, 3.38 ERA) start, while the Royals will counter with Zack Greinke (0-1, 2.25 ERA).

Dimers' top betting picks for Royals vs. White Sox, as well as game predictions and best odds, are featured below.

Who will win Royals vs. White Sox?

Based on cutting-edge machine learning and data, Dimers.com has simulated Wednesday's Royals-White Sox MLB matchup 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the White Sox a 66% chance of beating the Royals.

More: Royals vs. White Sox Simulated 10,000 Times

Royals vs. White Sox Current Odds

• Run Line: White Sox -1.5 (+120), Royals +1.5 (-135)
• Moneyline: White Sox -189, Royals +170
• Total: Over/Under 7 (+105/-120)

Run Line, Moneyline and Over/Under

The White Sox are currently -1.5 favorites versus the Royals, with +120 at PointsBet the best odds currently available.

For the underdog Royals (+1.5) to cover the run line, BetMGM has the best odds currently on offer at -135.

Caesars Sportsbook currently has the best moneyline odds for the White Sox at -189, which means you can risk $189 to win $100, for a total payout of $289, if they get the W.

On the other hand, Caesars Sportsbook also has the best moneyline odds for the Royals at +170, where you can bet $100 to profit $170, earning a total payout of $270, if they win.

The Over/Under sits at 7 with DraftKings Sportsbook, which currently has the best odds for the Over at +105, while BetMGM currently has the best odds for the Under at -120.

As always, make sure you check the sportsbooks you have access to in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 54% chance of covering the run line, while the 7-run Over/Under is a 52% chance of going Over.

More: Best Bets Today for All Major Sports

Best Bets for Royals vs. White Sox

• Run Line: White Sox -1.5 @ +120 via PointsBet (0.2% edge)
• Moneyline: White Sox @ -189 via Caesars Sportsbook (66% probability)
• Total: Over 7 @ +105 via DraftKings Sportsbook (52% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to bring you the best possible plays 24/7.

Even though the Royals are more likely to cover the run line, our best bet of White Sox -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Royals vs. White Sox Betting Guide

Use our interactive widget below to view the latest Moneyline, Over/Under and Run Line probabilities and odds for Kansas City vs. CHI White Sox, and click or tap on See Matchup for more.

Dimers has full betting coverage of Wednesday's Royals-White Sox matchup, including pregame predictions, computer picks, and live win probabilities.

Remember, DimersBOT updates regularly, so keep an eye on this page for any changes to our betting insights before Royals vs. White Sox on Wednesday April 27, 2022.

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Royals vs. White Sox 2022 Game Info

When do the White Sox play the Royals?

• Date: Wednesday April 27, 2022
• Time: 2:10PM ET / 11:10AM PT
• Venue: Guaranteed Rate Field

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What MLB games are on today?

The Royals and White Sox aren't the only two MLB teams you can bet on. DimersBOT never stops and we've got picks and best bets for each and every MLB game in our MLB Bet Hub section.

Not only do we provide with you top-notch predictions, but we also have recommended bets for the Run Line, Over/Under and Moneyline. Sound good? Check it out today!

While you're here, Dimers' Baseball Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds on the market.