Royals vs. Cardinals Prediction and Odds - Apr 13, 2022

The St Louis Cardinals and Kansas City Royals meet in the MLB at Busch Stadium on Wednesday, starting at 1:15PM EDT.

The Cardinals will have Adam Wainwright (1-0, 0.00 ERA) start, while the Royals will counter with Zack Greinke (0-0, 1.59 ERA).

Dimers' best betting picks for Royals vs. Cardinals, as well as game predictions and best odds, are featured below.

Who will win Royals vs. Cardinals?

Based on state-of-the-art computer power and data, Dimers.com has simulated Wednesday's Royals-Cardinals MLB matchup 10,000 times.

Dimers' revolutionary predictive analytics model, DimersBOT, gives the Cardinals a 60% chance of beating the Royals.

More: Free Betting Guide for Royals vs. Cardinals

Royals vs. Cardinals Current Odds

• Run Line: Cardinals -1.5, Royals +1.5
• Moneyline: Cardinals -145, Royals +132
• Total: Over/Under 8

Run Line, Moneyline and Over/Under

The Cardinals are -1.5 favorites against the Royals, with +136 at FanDuel Sportsbook the best odds currently available.

For the underdog Royals (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -149.

DraftKings Sportsbook currently has the best moneyline odds for the Cardinals at -145. That means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Royals at +132, where you can bet $100 to profit $132, earning a total payout of $232, if they win.

The Over/Under for total runs scored sits at 8 with FanDuel Sportsbook, which currently has the best odds for the Over at -108, while PointsBet currently has the best odds for the Under at +100.

As always, check out all the legal sportbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Royals (+1.5) are a 57% chance of covering the run line, while the Over/Under total of 8 runs is a 56% chance of going Over.

More: Predictions for Every MLB Game

Best Bets for Royals vs. Cardinals

• Run Line: Cardinals -1.5 @ +136 via FanDuel Sportsbook (1.0% edge)
• Moneyline: Cardinals @ -145 via DraftKings Sportsbook (60% probability)
• Total: Over 8 @ -108 via FanDuel Sportsbook (56% probability)

Dimers' best bets are based on detailed simulations and wagering intelligence to help you make smarter decisions with the legal sportsbooks in the United States.

Even though the Royals are more likely to cover the run line, our best bet of Cardinals -1.5 is based on the chance of that happening, according to DimersBOT, and the best odds available.

Royals vs. Cardinals Betting Guide

Use our interactive widget below to explore the latest Moneyline, Over/Under and Run Line probabilities and odds for Kansas City vs. St Louis, and click or tap on See Matchup for more.

Dimers has full betting coverage of Wednesday's Royals-Cardinals matchup, including pre-game predictions, computer picks, and live win probabilities.

Don't forget, DimersBOT updates frequently, so check this page for any changes to our betting analysis before Royals vs. Cardinals on Wednesday April 13, 2022.

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Royals vs. Cardinals 2022 Game Info

When do the Cardinals play the Royals?

• Date: Wednesday April 13, 2022
• Time: 1:15PM EDT / 10:15AM PDT
• Venue: Busch Stadium

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Want more MLB predictions like this?

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We use the power of predictive analytics to find edges in the markets so we can produce the most comprehensive MLB betting previews out there. We're able to do this by comparing our in-house probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

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Finally, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities matched against the best odds to win the World Series.