Red Sox vs. White Sox Prediction and Odds - May 25, 2022

The Chicago White Sox take on the Boston Red Sox in MLB action at Guaranteed Rate Field on Wednesday, starting at 8:10PM ET.

Lucas Giolito (2-1, 2.84 ERA) will get the ball for the White Sox, up against Rich Hill (1-1, 3.90 ERA) for the Red Sox.

Dimers' top betting picks for Red Sox vs. White Sox, as well as game predictions and best odds, are detailed in this article.

Today's Boston vs. CHI White Sox betting preview is presented by PointsBet, which has an awesome 5x $100 Risk-Free Bets promo for new customers.

Who will win Red Sox vs. White Sox?

Based on cutting-edge computer power and data, Dimers.com has simulated Wednesday's Red Sox-White Sox MLB game 10,000 times.

Dimers' renowned predictive analytics model, DimersBOT, gives the White Sox a 56% chance of defeating the Red Sox.

More: Red Sox vs. White Sox Simulated 10,000 Times

Red Sox vs. White Sox Current Odds

• Run Line: White Sox -1.5 (+140), Red Sox +1.5 (-160)
• Moneyline: White Sox -150, Red Sox +140
• Total: Over/Under 7.5 (-105/-110)

Run Line, Moneyline and Over/Under

The White Sox are -1.5 favorites against the Red Sox, with +140 at DraftKings Sportsbook the best odds currently available.

For the underdog Red Sox (+1.5) to cover the run line, DraftKings Sportsbook also has the best odds currently on offer at -160.

BetMGM currently has the best moneyline odds for the White Sox at -150, which means you can risk $150 to win $100, for a total payout of $250, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Red Sox at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored sits at 7.5 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -110.

As always, check out the sportsbooks you can bet with in your state for the best MLB odds and lines.

According to DimersBOT, the Red Sox (+1.5) are a 62% chance of covering the run line, while the Over/Under total of 7.5 runs is a 53% chance of going Over.

More: Track Your Bets via Dimers' Bet Center

Best Bets for Red Sox vs. White Sox

• Run Line: Red Sox +1.5 @ -160 via DraftKings Sportsbook (62% probability)
• Moneyline: Red Sox @ +140 via Caesars Sportsbook (2.5% edge)
• Total: Over 7.5 @ -105 via PointsBet (53% probability)

Dimers' best bets are based on world-class simulations and betting intelligence to help you make smarter decisions with the legal sportsbooks in the United States.

While the White Sox are more likely to win the game, according to DimersBOT, betting on the Red Sox moneyline is the best option due to the 2.5% edge identified when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges published on Dimers.com is pivotal to achieving long-term profitability as a bettor.

Red Sox vs. White Sox Betting Guide

Use our widget below to explore up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Boston vs. CHI White Sox, and click or tap on See Matchup to reveal more.

Dimers has full coverage of Wednesday's Red Sox-White Sox matchup, including pregame predictions, best betting picks, and live win probabilities.

Remember, DimersBOT updates frequently, so check this page for any changes to our betting analysis before Red Sox vs. White Sox on Wednesday May 25, 2022.

Best Betting Offer for Red Sox vs. White Sox

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Red Sox vs. White Sox 2022 Game Info

Wednesday's action between the White Sox and Red Sox at Guaranteed Rate Field is scheduled to commence at 8:10PM ET.

• Who: Chicago White Sox vs. Boston Red Sox
• Date: Wednesday May 25, 2022
• Time: 8:10PM ET / 5:10PM PT
• Venue: Guaranteed Rate Field

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Want more MLB predictions like this?

To get more MLB betting predictions like you've just read for Red Sox vs. White Sox, all you've gotta do is visit our MLB Betting News page. It's that easy – they're all there!

We use the power of predictive analytics to find edges in the markets so we can write the best MLB betting previews out there. We do this by comparing our own probabilities against the sportsbooks' odds (aka Vegas odds) the minute they go live.

So, get ahead of the game and beat the bookies today – it's only a click away.

While you're here, Dimers' Baseball Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds to win the World Series.