Red Sox vs. Rays Prediction and Odds - Apr 22, 2022

The Tampa Bay Rays square off with the Boston Red Sox in MLB action at Tropicana Field on Friday, starting at 7:10PM ET.

Corey Kluber (0-0, 1.86 ERA) will start for the Rays, pitting him against Michael Wacha (0-0, 0.96 ERA) for the Red Sox.

Dimers' free betting picks for Red Sox vs. Rays, as well as game predictions and best odds, are detailed below.

Who will win Red Sox vs. Rays?

Based on trusted machine learning and data, Dimers.com has simulated Friday's Red Sox-Rays MLB matchup 10,000 times.

Dimers' popular predictive analytics model, DimersBOT, currently gives the Rays a 55% chance of winning against the Red Sox.

More: Full Betting Guide for Red Sox vs. Rays

Red Sox vs. Rays Current Odds

• Run Line: Rays -1.5 (+140), Red Sox +1.5 (-156)
• Moneyline: Rays -145, Red Sox +140
• Total: Over/Under 7.5 (-120/+100)

Run Line, Moneyline and Over/Under

The Rays are -1.5 favorites versus the Red Sox, with +140 at BetMGM the best odds currently available.

For the underdog Red Sox (+1.5) to cover the run line, FanDuel Sportsbook has the best odds currently on offer at -156.

BetMGM currently has the best moneyline odds for the Rays at -145. That means you can risk $145 to win $100, for a total payout of $245, if they get the W.

Meanwhile, Caesars Sportsbook currently has the best moneyline odds for the Red Sox at +140, where you can bet $100 to profit $140, earning a total payout of $240, if they win.

The Over/Under for total runs scored is set at 7.5 with DraftKings Sportsbook, which currently has the best odds for the Over at -120, as well as the best odds for the Under at +100.

As always, make sure you check all the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Red Sox (+1.5) are a 63% chance of covering the run line, while the 7.5-run Over/Under is a 57% chance of going Over.

More: Today's Best Bets for All Major Sports

Best Bets for Red Sox vs. Rays

• Run Line: Red Sox +1.5 @ -156 via FanDuel Sportsbook (63% probability)
• Moneyline: Red Sox @ +140 via Caesars Sportsbook (3.5% edge)
• Total: Over 7.5 @ -120 via DraftKings Sportsbook (57% probability)

Dimers' best bets are based on complex simulations and wagering intelligence to bring you the best possible plays 24/7/365.

While the Rays are more likely to win the game, according to DimersBOT, taking the Red Sox moneyline is the best option due to the 3.5% edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability.

Red Sox vs. Rays Probabilities

Use our interactive widget below to view up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Boston vs. Tampa Bay, and click or tap on See Matchup to reveal more.

Dimers has full betting coverage of Friday's Red Sox-Rays matchup, including pregame predictions, best betting picks, and live scores.

Don't forget, DimersBOT updates often, so refresh this article for the latest betting insights before Red Sox vs. Rays on Friday April 22, 2022.

Top Sportsbook Promo for Red Sox vs. Rays

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Note: when you click or tap on a link on Dimers that leads to a third-party website that we have a commercial arrangement with (such as a sportsbook), we may earn a referral fee.

Red Sox vs. Rays 2022 Game Info

When do the Rays play the Red Sox?

• Date: Friday April 22, 2022
• Time: 7:10PM ET / 4:10PM PT
• Venue: Tropicana Field

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What MLB games are on today?

Now you've got the 411 on Red Sox vs. Rays, take a look at the latest betting analysis for all upcoming MLB games in Dimers' MLB Bet Hub, where you can find probabilities and odds, as well as our best bets for every single MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

Lastly, Dimers' MLB Futures page is our in-house approach to revealing who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.