Red Sox vs. Guardians Prediction and Odds - Jun 25, 2022

The Cleveland Guardians and Boston Red Sox clash in MLB at Progressive Field on Saturday, starting at 6:10PM ET.

The Guardians will have Shane Bieber (3-3, 3.00 ERA) start, up against Josh Winckowski (2-1, 3.68 ERA) for the Red Sox.

Dimers' best betting picks for Red Sox vs. Guardians, plus game predictions and best odds, are detailed below.

Who will win Red Sox vs. Guardians?

Based on advanced computer power and data, Dimers.com has simulated Saturday's Red Sox-Guardians MLB game 10,000 times.

Dimers' independent predictive analytics model, DimersBOT, can't split the two teams, giving both the Red Sox and Guardians a 50% chance of winning the game.

More: Red Sox vs. Guardians Simulated 10K Times

Red Sox vs. Guardians Game Odds

• Run Line: Guardians -1.5 (+130), Red Sox +1.5 (-145)
• Moneyline: Guardians -160, Red Sox +142
• Total: Over/Under 8.5 (-105/-115)

Run Line, Moneyline and Over/Under

The Guardians are -1.5 favorites versus the Red Sox, with +130 at PointsBet the best odds currently available.

For the underdog Red Sox (+1.5) to cover the run line, Caesars Sportsbook has the best odds currently on offer at -145.

BetMGM currently has the best moneyline odds for the Guardians at -160, which means you can risk $160 to win $100, for a total payout of $260, if they get the W.

Elsewhere, FanDuel Sportsbook currently has the best moneyline odds for the Red Sox at +142, where you can bet $100 to profit $142, earning a total payout of $242, if they win.

The Over/Under for total runs scored is set at 8.5 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -115.

As always, check out all of the sportsbooks that are available in your state for the best MLB odds and lines.

According to DimersBOT, the Red Sox (+1.5) are a 60% chance of covering the run line, while the 8.5-run Over/Under is a 51% chance of going Over.

More: Best Bets for Every MLB Matchup

Best Bets for Red Sox vs. Guardians

• Run Line: Red Sox +1.5 @ -145 via Caesars Sportsbook (60% probability)
• Moneyline: Red Sox @ +142 via FanDuel Sportsbook (50% probability) 🔥
• Total: Over 8.5 @ -105 via PointsBet (51% probability)

Any time you see a 🔥, that means you've found one of Dimers' best bets of the day across all sports.

Our best bets are based on complex simulations and gambling expertise to bring you the best possible plays every day of the year.

Red Sox vs. Guardians Betting Guide

Use our interactive widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Boston vs. Cleveland, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Red Sox-Guardians matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates often, so keep checking this article for any changes to our betting insights before Red Sox vs. Guardians on Saturday June 25, 2022.

Risk-Free Bet for Red Sox vs. Guardians

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Red Sox vs. Guardians 2022 Game Info

Saturday's action between the Guardians and Red Sox at Progressive Field is scheduled to begin at 6:10PM ET.

• Who: Cleveland Guardians vs. Boston Red Sox
• Date: Saturday June 25, 2022
• Time: 6:10PM ET / 3:10PM PT
• Venue: Progressive Field

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Want more MLB predictions like this?

So, you liked our Red Sox vs. Guardians betting analysis? Awesome. Did you know our MLB Betting News page has a detailed betting preview for every MLB game as soon as the sportsbooks put out their odds?

That's right, our predictive analytics model then compares those odds (aka Vegas odds) against its own probabilities to find value in the markets, which allows us to create the most authoritative MLB betting previews and beat the public and the sportsbooks to the punch.

It's only a click away, so why not take a look around?

Lastly, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities paired with the best odds to win the World Series.