Rays vs. Orioles Prediction and Odds - May 21, 2022

The Baltimore Orioles and Tampa Bay Rays are scheduled to meet in MLB at Oriole Park at Camden Yards on Saturday, starting at 7:05PM ET.

The Orioles will have Kyle Bradish (1-2, 5.06 ERA) start, while the Rays are going with Jeffrey Springs (1-1, 1.66 ERA).

Dimers' free betting picks for Rays vs. Orioles, plus game predictions and best odds, are featured in this article.

This Tampa Bay vs. Baltimore betting analysis is sponsored by PointsBet, which has a 5x $100 Risk-Free Bets promo for new customers.

Who will win Rays vs. Orioles?

Based on cutting-edge computer power and data, Dimers.com has simulated Saturday's Rays-Orioles MLB game 10,000 times.

Dimers' leading predictive analytics model, DimersBOT, currently gives the Rays a 54% chance of getting the W against the Orioles .

More: Full Betting Guide for Rays vs. Orioles

Rays vs. Orioles Game Odds

• Run Line: Orioles +1.5 (-145), Rays -1.5 (+125)
• Moneyline: Orioles +110, Rays -130
• Total: Over/Under 8.5 (-105/-105)

Run Line, Moneyline and Over/Under

The Orioles are +1.5 underdogs against the Rays, with -145 at Caesars Sportsbook the best odds currently available.

For the favored Rays (-1.5) to cover the run line, DraftKings Sportsbook has the best odds currently on offer at +125.

BetMGM currently has the best moneyline odds for the Orioles at +110, which means you can bet $100 to profit $110, earning a total payout of $210, if they win.

On the other hand, Caesars Sportsbook currently has the best moneyline odds for the Rays at -130, where you can risk $130 to win $100, for a total payout of $230, if they come out on top.

The Over/Under for total runs scored is set at 8.5 with PointsBet, which currently has the best odds for the Over at -105, while Caesars Sportsbook currently has the best odds for the Under at -105.

As always, make sure you check all the sportsbooks available in your state for the best MLB odds and lines.

According to DimersBOT, the Orioles (+1.5) are a 63% chance of covering the run line, while the Over/Under total of 8.5 runs is a 52% chance of going Under.

More: Best Bets for Every MLB Game

Best Bets for Rays vs. Orioles

• Run Line: Orioles +1.5 @ -145 via Caesars Sportsbook (63% probability)
• Moneyline: Orioles @ +110 via BetMGM
• Total: Under 8.5 @ -105 via Caesars Sportsbook (52% probability)

Dimers' best bets are based on world-class simulations and wagering intelligence to help you make more informed investments with the legal sportsbooks in America.

While the Rays are more likely to win the game, according to DimersBOT, taking the Orioles moneyline is the best option due to the edge found when comparing our data-led probabilities to the sportsbooks' odds currently on offer.

Taking advantage of the edges seen on Dimers.com is one of the keys to achieving long-term profitability.

Rays vs. Orioles Probabilities

Use our dynamic widget below to see up-to-date Moneyline, Over/Under and Run Line probabilities and odds for Tampa Bay vs. Baltimore, and click or tap on See Matchup for more.

Dimers has full coverage of Saturday's Rays-Orioles matchup, including pregame predictions, best betting picks, and live win probabilities.

Don't forget, DimersBOT updates regularly, so refresh this article for any changes to our betting analysis before Rays vs. Orioles on Saturday May 21, 2022.

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Rays vs. Orioles 2022 Game Info

Saturday's game between the Orioles and Rays at Oriole Park at Camden Yards is scheduled to start at 7:05PM ET.

• Date: Saturday May 21, 2022
• Time: 7:05PM ET / 4:05PM PT
• Venue: Oriole Park at Camden Yards

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What MLB games are on today?

Now you've got the 411 on Rays vs. Orioles, see the latest betting analysis for all upcoming MLB games in Dimers' MLB Bet Hub. There you can find probabilities and odds, plus our best bets for each and every MLB matchup.

Want a pick for the Run Line? You got it. How about the Over/Under? Yup, got that too. The Moneyline? Yes sir. And these picks are good, I mean REALLY good. Take a look now!

While you're here, Dimers' MLB Futures page is our in-house approach to determining who will win the 2022 World Series, with our data-led probabilities compared to the best odds available.