Radford vs. USC Upstate prediction: USC Upstate favored to win men's college basketball matchup [12/31/2025]

USC Upstate will square off with Radford, in what is expected to be a close Men's College Basketball game, at G.B. Hodge Center on Wednesday, starting at 2:00 PM ET.

Based on updated simulation results, Dimers' proven college basketball model gives USC Upstate a slight edge with a 52% win probability over Radford.

This article offers an expanded analysis of Wednesday's Radford vs. USC Upstate matchup, including an expanded look at the predicted score, best bets and picks.

Radford vs. USC Upstate prediction: Who will win and cover?

Using powerful machine learning and data, we have simulated the result of Wednesday's NCAA basketball matchup between Radford and USC Upstate 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model gives USC Upstate a 52% chance of defeating Radford. Our predicted final score has USC Upstate winning 79-78.

According to our model, Radford (+1.5) has a 55% chance of covering the spread, while the over/under total of 158.5 points has a 52% chance of staying under.

Radford vs. USC Upstate odds

We have sourced the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Radford vs. USC Upstate picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:

According to our men's college basketball best bets, the top play to make on this game is Radford +1.5 at the spread.

Radford vs. USC Upstate game-day updates and essential details

Wednesday's men's college basketball matchup between USC Upstate and Radford at G.B. Hodge Center is scheduled to commence at 2:00 PM ET.

• Who: Radford vs. USC Upstate
• Date: Wednesday, December 31, 2025
• Time: 2:00 PM ET/11:00AM PT
• Venue: G.B. Hodge Center

Conclusion

We predict USC Upstate, with a 52% win probability, will likely beat Radford on Wednesday.

AI and automation have enhanced this article to quickly deliver accurate Radford vs. USC Upstate insights, with human oversight ensuring high editorial quality. Our predictions are drawn from the latest data to help you make informed decisions. For additional resources and advice on responsible gambling, please call 1-800-GAMBLER.

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