Radford vs. USC Upstate prediction: Radford favored to win men's college basketball matchup [12/31/2025]

USC Upstate and Radford will lock horns in men's college basketball action at G.B. Hodge Center on Wednesday, with tipoff at 2:00 PM ET.

Based on updated simulation results, Dimers' advanced college basketball model projects Radford as the most likely winner of the Radford vs. USC Upstate game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Radford vs. USC Upstate prediction: Who will win and cover?

Using powerful machine learning and statistical analysis, we have simulated the outcome of Wednesday's NCAA basketball matchup between Radford and USC Upstate 10,000 times as part of our men's college basketball predictions coverage.

Our leading predictive model currently gives Radford a 55% chance of beating USC Upstate. Our predicted final score has Radford winning 79-78.

According to our model, Radford (+1.5) has a 56% chance of covering the spread, while the 159.5-point over/under has a 52% chance of staying under.

Radford vs. USC Upstate odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Radford vs. USC Upstate picks and best bet

After matching our predictions against the best available odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: