Portland vs. Oregon prediction: Oregon favored to win men's college basketball matchup [12/17/2025]

Men's college basketball action continues on Wednesday at 11:00 PM ET as Portland squares off with Oregon in men's college basketball action at Matthew Knight Arena.

Based on the latest simulation results, Dimers' proven college basketball model projects Oregon as the most likely winner of the Portland vs. Oregon game.

This article offers an expanded analysis of Wednesday's matchup, including an expanded look at the predicted score, best bets and picks.

Portland vs. Oregon prediction: Who will win and cover?

Using trusted machine learning and data, we have simulated the result of Wednesday's NCAA basketball game between Portland and Oregon 10,000 times as part of our men's college basketball predictions coverage.

Our independent predictive model currently gives Oregon a 97% chance of defeating Portland. Our predicted final score has Oregon winning 87-65.

According to our model, Oregon (-20.5) has a 53% chance of covering the spread, while the 154.5-point over/under has a 54% chance of staying under.

Portland vs. Oregon odds

We have researched the best men's college basketball odds in America for this game, which are listed here:

All odds are correct at the time of publication and are subject to change.

Portland vs. Oregon picks and best bet

After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below: