May 20, 2026
Red Sox vs. Royals prediction: Kansas City favored to win Wednesday's MLB matchup [5/20/2026]
Read Article Pirates vs. Cardinals prediction: St. Louis favored to win Wednesday's MLB matchup [5/20/2026]
Updated: | First published:
Written by Dave Garofolo, Content Producer
Get Pittsburgh Pirates vs St. Louis Cardinals predictions for MLB Wednesday.
MLB action continues on Wednesday at 7:45 PM ET as the Pittsburgh Pirates square off with the St. Louis Cardinals at Busch Stadium.
Michael McGreevy (3-2, 2.10 ERA) will be on the bump for the Cardinals, while the Pirates have opted for Carmen Mlodzinski (3-3, 4.40 ERA).
Based on the latest simulation results, Dimers' proven MLB model gives the Cardinals a slight edge with a 53% win probability over the Pirates.
This article offers an expanded analysis of Wednesday's Pirates vs. Cardinals matchup, including best bets and picks.
Pirates vs. Cardinals prediction: Who will win?
Using powerful machine learning and statistical analysis, we have simulated the result of Wednesday's MLB matchup between the Pirates and Cardinals, forming part of our MLB predictions coverage.
Our independent predictive model gives the Cardinals a 53% chance of beating the Pirates.
According to our model, the over/under total of 7.5 runs has a 54% chance of going over.
Pirates vs. Cardinals odds [5/20/2026]
We have sourced the best MLB odds in America for this game, which are listed here:
| Bet Type | Pirates | Cardinals |
|---|---|---|
| Moneyline | +100 | -110 |
| Total | o7.5 (-110) | u7.5 (-107) |
All odds are correct at the time of publication and are subject to change.
Pirates vs. Cardinals picks and best bet
After matching our predictions against the best current odds, we can reveal our picks for each of the major markets. Plus, find our best bet for the game below:
| Bet Type | Pick | Bet Now |
|---|---|---|
| Moneyline | Cardinals | -110 |
| Total | Over 7.5 | -110 |
According to our best MLB bets, the top play to make on this game is Over 7.5 total runs.
These picks are based on our probabilities matched against the implied probabilities from the sportsbook odds.
Pirates vs. Cardinals game-day updates and essential details
Wednesday's MLB action between the Cardinals and Pirates at Busch Stadium is scheduled to commence at 7:45 PM ET.
- Who: Pittsburgh Pirates vs. St. Louis Cardinals
- Date: Wednesday, May 20, 2026
- Time: 7:45 PM ET/4:45PM PT
- Venue: Busch Stadium
Conclusion
We predict the Cardinals, with a 53% win probability, will likely beat the Pirates in Wednesday's MLB matchup.
Additional tools and information for betting safely can be found in our Responsible Gambling hub.
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Dave Garofolo uses sophisticated AI-driven analytics to make predictions and evaluate player performances in the NBA, MLB, NFL, NHL, NCAAM, and PGA TOUR tournaments, crafting insightful game and prop previews.
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